ArticleData in brief2019
Screening dataset of food components that enhance transcriptional activity of PGC1-beta.
Article in Data in brief, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism.International journal of molecular sciences · 2021Review
- Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression.Biochemistry and biophysics reports · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PGC-1β is a transcriptional co-activator of nuclear receptors, which acts to increase energy expenditure. PGC-1β fused to GAL4 DNA-binding domain transfected in HEK293T cells showed a reporter luciferase activity. We screened food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β. We found that soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β, see "Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression" [1]. The list of 166 compounds and their reporter activity is shown here.
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Registered trials
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