ArticleZoological letters2019
Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa.
Article in Zoological letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Sperm Ion Transporters and Channels in Human Asthenozoospermia: Genetic Etiology, Lessons from Animal Models, and Clinical Perspectives.International journal of molecular sciences · 2022Pooled it
- Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCOProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- pH Homeodynamics and Male Fertility: A Coordinated Regulation of Acid-Based Balance during Sperm Journey to Fertilization.Biomolecules · 2024Review
- Review
- The cAMP signaling module regulates sperm motility in the liverwortProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Role of Soluble Adenylyl Cyclase in the Regulation of Flagellar Motility in Ascidian Sperm.Biomolecules · 2023Article
- Architecture and rearrangements of a sperm-specific NaResearch square · 2023Article
- NaInternational journal of molecular sciences · 2023Review
- Sperm calcium flux and membrane potential hyperpolarization observed in the Mexican big-eared bat Corynorhinus mexicanus.The Journal of experimental biology · 2023Article
- Molecular mechanisms of sperm motility are conserved in an early-branching metazoan.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Polyamines Influence Mouse Sperm Channels Activity.International journal of molecular sciences · 2021Article
- De novo transcriptome assembly from the gonads of a scleractinian coral, Euphyllia ancora: molecular mechanisms underlying scleractinian gametogenesis.BMC genomics · 2020Article
- Differences and Similarities: The Richness of Comparative Sperm Physiology.Physiology (Bethesda, Md.) · 2020Review
- Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce CaFrontiers in physiology · 2020Article
- Activation of motility and chemotaxis in the spermatozoa.Reproductive medicine and biologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCatSper is a sperm-specific calcium ion (Ca
resultsWe carried out a comparative genomic analysis to explore phylogenetic relationships among CatSper, sNHE and sAC in eukaryotes. We found that sNHE occurs only in Metazoa, although sAC occurs widely across eukaryotes. In animals, we found correlated and restricted distribution patterns of the three proteins, suggesting coevolution among them in the Metazoa. Namely, nearly all species in which CatSper is conserved also preserve sNHE and sAC. In contrast, in species without sAC, neither CatSper nor sNHE is conserved. On the other hand, the distribution of another testis-specific NHE (NHA, a product of the
conclusionsOur results suggest that CatSper, sNHE and sAC form prototypical machinery that functions in regulating sperm flagellar beating in Metazoa. In non-metazoan species, CatSper may be regulated by other H
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