ArticleBiomaterials research2019
Effects of micro-porosity and local BMP-2 administration on bioresorption of β-TCP and new bone formation.
Article in Biomaterials research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Bone Morphogenetic Protein (BMP) 9 Outperforms BMP2 in Osteogenesis and Osseointegration: In Vitro and In Vivo.Clinical implant dentistry and related research · 2026Article
- Alterations in the Physicochemical and Structural Properties of a Ceramic-Polymer Composite Induced by the Substitution of Hydroxyapatite with Fluorapatite.Materials (Basel, Switzerland) · 2025Article
- Calcium Phosphate Honeycomb Scaffolds with Tailored Microporous Walls Using Phase Separation-Assisted Digital Light Processing.Materials (Basel, Switzerland) · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Enhancing Bone Repair with β-TCP-Based Composite Scaffolds: A Review of Design Strategies and Biological Mechanisms.Orthopedic research and reviews · 2025Review
- Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model.Regenerative biomaterials · 2025Article
- Three-dimensional printed calcium phosphate scaffolds emulate bone microstructure to promote bone regrowth and repair.Journal of materials science. Materials in medicine · 2024Article
- MgO-enhanced β-TCP promotes osteogenesis in both in vitro and in vivo rat models.Scientific reports · 2024Article
- Improvement of absorbability, osteoconductivity, and strength of a β-tricalcium phosphate spacer for opening wedge high tibial osteotomy: clinical evaluations with 106 patients.BMC musculoskeletal disorders · 2024Article
- Magnesium-Doped Nano-Hydroxyapatite/Polyvinyl Alcohol/Chitosan Composite Hydrogel: Preparation and Characterization.International journal of nanomedicine · 2024Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Acetabular fracture and central hip dislocation in osteogenesis imperfecta child treated surgically with bone grafts augmented by recombinant human bone morphogenetic protein-2: A rare case report.International journal of surgery case reports · 2023Article
- Dentin, Dentin Graft, and Bone Graft: Microscopic and Spectroscopic Analysis.Journal of functional biomaterials · 2023Article
- Article
- Sudoku of porous, injectable calcium phosphate cements - Path to osteoinductivity.Bioactive materials · 2022Review
- Effects of ultraviolet irradiation on beta-tricalcium phosphate as a bone graft substitute.Odontology · 2022Article
- Bone Tissue Engineering in the Treatment of Bone Defects.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Combined use of beta-tricalcium phosphate with different porosities can accelerate bone remodelling in open-wedge high tibial osteotomy.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2022Article
- Effects of rhBMP-2-loaded hydroxyapatite granules/beta-tricalcium phosphate hydrogel (HA/β-TCP/hydrogel) composite on a rat model of caudal intervertebral fusion.Scientific reports · 2022Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been reported that the microporous structure of calcium phosphate (CaP) ceramics is important to osteoconduction. Bone morphogenetic protein-2 (BMP-2) has been shown to be a promising alternative to bone grafting and a therapeutic agent promoting bone regeneration when delivered locally. The aim of this study was to evaluate the effects of micro-porosity within beta-tricalcium phosphate (β-TCP) cylinders and local BMP-2 administration on β-TCP resorption and new bone formation.
methodsBilateral cylindrical bone defects were created in rabbit distal femora, and the defects were filled with β-TCP. Rabbits were divided into 3 groups; defects were filled with a β-TCP cylinder with a total of approximately 60% porosity (Group A: 13.4% micro- and 46.9% macropore, Group B: 38.5% micro- and 20.3% macropore, Group C: the same micro- and macro-porosity as in group B supplemented with BMP-2). Rabbits were sacrificed 4, 8, 12, and 24 weeks postoperatively.
resultsThe number of TRAP-positive cells and new bone formation in group B were significantly greater than those in group A at every period. The amount of residual β-TCP in group C was less than that in group B at all time periods, resulting in significantly more new bone formation in group C at 8 and 12 weeks. The number of TRAP-positive cells in group C was maximum at 4 weeks.
conclusionsThese results suggest that the amount of submicron microporous structure and local BMP-2 administration accelerated both osteoclastic resorption of β-TCP and new bone formation, probably through a coupling-like phenomenon between resorption and new bone formation.
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