Evidence map›Paper›PMID 31372221›Full record

ArticleJournal of materials chemistry. B2018

Hyaluronic Acid Grafted Nanoparticles of a Platinum(II)-Silicon(IV) Phthalocyanine Conjugate for Tumor and Mitochondria-Targeted Photodynamic Therapy in Red Light.

Koushambi Mitra, Montserrat Samso, Charles E Lyons, Matthew C T Hartman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Monofunctional Platinum(II) Anticancer Agents.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  3. Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  4. Mitochondria-Targeted Nanomedicine for Enhanced Efficacy of Cancer Therapy.Frontiers in bioengineering and biotechnology · 2021
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Koushambi MitraDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA.
Montserrat SamsoDepartment of Physiology and Biophysics, Virginia Commonwealth University, 1101 E. Marshall St., Richmond, VA 23298, USA.
Charles E LyonsMassey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA.
Matthew C T HartmanDepartment of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA.
University of Richmond · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
RyR architecture and gatekeeping of internal calcium storesR01AR068431 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAMSO, MONTSERRAT · 2017 to 2021
$2.0M
NCI NIH HHS P30 CA016059NIAMS NIH HHS R01 AR068431
6 · The paper itself

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc-Pt-HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc-Pt-HA conjugate showed specific uptake, photo-enhanced cytotoxicity (~1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorHEK293 CellsHumansHyaluronan ReceptorsHyaluronic AcidIndolesIsoindolesLightMitochondriaNanoparticlesPhotochemotherapyPhotosensitizing AgentsPlatinumSiliconAntineoplastic AgentsCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidIndolesIsoindolesPhotosensitizing AgentsphthalocyaninePlatinumSilicon

Identifiers

PMID31372221
PMCPMC6675464
OpenAlexW2898215090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.