ArticleBiomicrofluidics2019
Deformation and dynamics of erythrocytes govern their traversal through microfluidic devices with a deterministic lateral displacement architecture.
Article in Biomicrofluidics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A Review of the Application of Compliance Phenomenon in Particle Separation Within Microfluidic Systems.Micromachines · 2025Review
- Assessing Differential Particle Deformability under Microfluidic Flow Conditions.ACS biomaterials science & engineering · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- Geometric structure design of passive label-free microfluidic systems for biological micro-object separation.Microsystems & nanoengineering · 2022Review
- Cell Separations and Sorting.Analytical chemistry · 2020Review
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Authors and funding
4 authors.
Funding
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Abstract
Deterministic lateral displacement (DLD) microfluidic devices promise versatile and precise processing of biological samples. However, this prospect has been realized so far only for rigid spherical particles and remains limited for biological cells due to the complexity of cell dynamics and deformation in microfluidic flow. We employ mesoscopic hydrodynamics simulations of red blood cells (RBCs) in DLD devices with circular posts to better understand the interplay between cell behavior in complex microfluidic flow and sorting capabilities of such devices. We construct a mode diagram of RBC behavior (e.g., displacement, zig-zagging, and intermediate modes) and identify several regimes of RBC dynamics (e.g., tumbling, tank-treading, and trilobe motion). Furthermore, we link the complex interaction dynamics of RBCs with the post to their effective cell size and discuss relevant physical mechanisms governing the dynamic cell states. In conclusion, sorting of RBCs in DLD devices based on their shear elasticity is, in general, possible but requires fine-tuning of flow conditions to targeted mechanical properties of the RBCs.
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Registered trials
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