ArticlePakistan journal of medical sciences
Intravenous thrombolysis in combination with mild hypothermia therapy in the treatment of acute cerebral infarction.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Reducing stroke-associated pneumonia through pulmonary rehabilitation in moderate-to-severe acute ischemic stroke.European journal of medical research · 2025Trial
- Trial
- Head mild hypothermia treatment after successful mechanical thrombectomy in anterior circulation large-vessel occlusion acute cerebral infarction.European journal of medical research · 2026Article
- Target temperature management in acute ischemic stroke.Frontiers in molecular biosciences · 2026Review
- Article
- Effectiveness of Combined Thrombolysis and Mild Hypothermia Therapy in Acute Cerebral Infarction: A Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- The clinical efficacy of compound Danshen injection on acute cerebral infarction and on the changes in the CRP, D-dimer, and IL-6 levels.American journal of translational research · 2021Article
- Ginkgo biloba Damo injection combined with troxerutin regulates the TLR4/NF-κB pathway and promotes the recovery of patients with acute cerebral infarction.American journal of translational research · 2021Article
- Protective effect of hypothermia and vitamin E on spermatogenic function after reduction of testicular torsion in rats.Experimental and therapeutic medicine · 2020Article
- Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury.CNS neuroscience & therapeutics · 2020Article
- Hypothermic neuroprotection against acute ischemic stroke: The 2019 update.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Effect of intravenous thrombolysis combined with endovascular treatment on vascular recanalization rate and peak systolic velocity in patients with acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Clinical observation of mild hypothermia combined with intravenous thrombolysis in treating patients with acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Mesenchymal Stem Cell-Induced Anti-Neuroinflammation Against Traumatic Brain Injury.Cell transplantationArticle
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Authors and funding
3 authors.
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Abstract
objectiveTo investigate the efficacy of recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis in combination with mild hypothermia therapy in the treatment of acute cerebral infarction.
methodsOne hundred and thirty-two patients with acute cerebral infarction who were admitted to our hospital were selected and grouped into a control group and an observation group, 66 each group. Patients in the control group were given conventional treatment in combination with local mild hypothermia therapy, and patients in the observation group were given rt-PA intravenous thrombolysis on the basis of conventional treatment and local mild hypothermia therapy. National institute of health stroke scale (NIHSS) score and intracranial pressure (ICP) of the two groups before and after treatment was recorded. The efficacy of the two groups was evaluated. The modified Rankin scale (MRS) score was followed up for three months. The blood samples of the patients were collected before and after thrombolysis. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels in the plasma were detected.
resultsThe NIHSS score of the two groups decreased in the 1
conclusionrt-PA intravenous thrombolysis in combination with mild hypothermia therapy has significant efficacy in the treatment of acute cerebral infarction. It can effectively relieve neurological function. Its action mechanism may be realized by relieving oxidative stress response.
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