Evidence map›Paper›PMID 31372046›Full record

ArticleCancer management and research2019

Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies.

Jiao Hu, Yu Cui, Peihua Liu, Xu Zhou, Wenbiao Ren, Jinbo Chen, Xiongbing Zu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Penile cancer: Updates in systemic therapy.Asian journal of urology · 2022
    Review
  11. Article
  12. Article
  13. Clinical Application of Noninflating Video-Endoscopic Inguinal Lymph Node Dissection.Computational and mathematical methods in medicine · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Tumor Microenvironment in Penile Cancer.Advances in experimental medicine and biology · 2020
    Review
  18. Article
  19. Predictive histopathological factors of nodal metastasis in penile cancer.International braz j urol : official journal of the Brazilian Society of Urology
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiao HuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Yu CuiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Peihua LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Xu ZhouReproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Wenbiao RenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Jinbo ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Xiongbing ZuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInguinal lymph node metastasis (LNM) is one of the most significant prognostic factors for patients with penile cancer. This study aimed to identify potential predictors of inguinal LNM. PATIENTS AND

methodsA comprehensive search of the PubMed, Embase, and Cochrane Library databases for studies that reported predictors of inguinal LNM in penile cancer was performed. Finally, we selected 42 eligible studies with 4,802 patients. Accumulative analyses of odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were performed. All analyses were performed by using Review Manager software version 5.3.

resultsAmong the 4,802 patients, 1,706 (36%) were diagnosed with inguinal LNM. Predictors of LNM included two categories: tumor-associated biomarkers and invasive clinicopathologic characteristics. Biomarker-specific predictors: the program death ligand 1 (PD-L1) overexpression (OR=2.55,

conclusionCurrent meta-analysis conclusively identified valuable predictors of inguinal LNM for patients with penile cancer. However, high-quality studies are warranted to further validate our conclusions. The intrinsic link between these predictors needs to be further investigated to create an accurate mathematical prediction model for LNM.

Indexed as

inguinal lymph node metastasismeta-analysispenile cancerpredictor

Identifiers

PMID31372046
PMCPMC6628149
OpenAlexW2957297527

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.