ArticleNeuropsychiatric disease and treatment2019
Exercise training increases spatial memory via reducing contralateral hippocampal NMDAR subunits expression in intracerebral hemorrhage rats.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mechanisms of exercise-based rehabilitation following intracerebral hemorrhage: insights from preclinical evidence.Frontiers in pharmacology · 2026Pooled it
- Mechanisms of memory impairment in animal models of nontraumatic intracranial hemorrhage: A systematic review of the literature.Brain hemorrhages · 2022Pooled it
- Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications.Frontiers in aging neuroscience · 2026Review
- High-intensity training on CREB activation for improving brain health: a narrative review of possible molecular talks.Frontiers in endocrinology · 2024Review
- Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.Journal of molecular neuroscience : MN · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
objectiveThe aim of this study was to explore the effect of exercise training on spatial memory in rats with intracerebral hemorrhage (ICH) and to analyze its related neurobiological mechanisms.
methodsA total of 26 Sprague-Dawley rats were randomly divided into 3 groups: exercise (EX) group undergoing exercise training after ICH, model (MD) group and sham-operated (SM) group. The ICH rats model were induced by infusion of type I collagenase into caudate nucleus of rats. Morris water maze (MWM) test was performed at the same time in three groups to evaluate spatial memory in rats. All rats were sacrificed for evaluation of expression of N-methyl-d-aspartate receptor 1 (NR1) and N-methyl-d-aspartate receptor 2B (NR2B) in the CA3 region of the hippocampus by Western blot.
resultsMWM test results showed that the spatial memory of MD group was significantly decreased compared to that of SM operation group (
conclusionExercise training improves the spatial memory in the rats with ICH via down-regulating NR1 and NR2B expression in CA3 region of the contralateral hippocampus.
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