ArticleNeuropsychiatric disease and treatment2019
Febrile infection-related epilepsy syndrome (FIRES): prevalence, impact and management strategies.
Article in Neuropsychiatric disease and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Case Report: Tocilizumab in pediatric febrile infection-related epilepsy syndrome.Frontiers in immunology · 2026Article
- Metabolism-corrected propofol exposure intensity and long-term intelligence quotient in pediatric febrile infection-related epilepsy syndrome: a retrospective cohort study.Frontiers in medicine · 2026Article
- Status Epilepsy Syndromes Made Easy: Pediatric Perspectives.Children (Basel, Switzerland) · 2025Review
- Febrile Infection-Related Epilepsy Syndrome (FIRES) in children: a retrospective cohort study.European journal of pediatrics · 2025Article
- Lidocaine as a potential anti-seizure therapy for pediatric FIRES: a promising therapeutic approach.Frontiers in pediatrics · 2025Article
- New-Onset Refractory Status Epilepticus and Febrile Infection-Related Epilepsy Syndrome Cases in Children: A Retrospective Cohort Study in South of Iran.Iranian journal of child neurology · 2025Article
- Consensus Guideline on the Management of Epilepsy in Egypt: A National Delphi Consensus Study.Epilepsia open · 2024Article
- A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory.Frontiers in molecular neuroscience · 2024Review
- The Beneficial Outcome of Subsequent Treatment with Anakinra during the Chronic Phase of Febrile Infection-Related Epilepsy Syndrome (FIRES): A Case Report.Neurology international · 2023Article
- Cannabidiol in the acute phase of febrile infection-related epilepsy syndrome (FIRES).Epilepsia open · 2023Article
- The effect of cannabidiol on seizure features and quality of life in drug-resistant frontal lobe epilepsy patients: a triple-blind controlled trial.Frontiers in neurology · 2023Article
- Febrile infection-related Epilepsy Syndrome (FIRES): a severe encephalopathy with status epilepticus. Literature review and presentation of two new cases.Italian journal of pediatrics · 2022Review
- A Comprehensive Review of Pediatric Acute Encephalopathy.Journal of clinical medicine · 2022Review
- New-onset refractory status epilepticus (NORSE) in paediatric patients: causes, characteristics and outcomes.BMJ neurology open · 2022Article
- Sevoflurane as bridge therapy for plasma exchange and Anakinra in febrile infection-related epilepsy syndrome.Epilepsia open · 2021Article
- Ketogenic diet (KD) therapy in the acute phase of febrile infection-related epilepsy syndrome (FIRES): a case report.Translational pediatrics · 2021Article
- The off-label use of anakinra in pediatric systemic autoinflammatory diseases.Therapeutic advances in musculoskeletal disease · 2020Review
- Utility and Safety of Perampanel in Pediatric FIRES and Other Drug-Resistant Epilepsies.Child neurology openArticle
- [Electroencephalogram characteristics of 26 children with febrile infection-related epilepsy syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Febrile infection-related epilepsy syndrome (FIRES) is a rare catastrophic epileptic encephalopathy with a yet undefined etiology, affecting healthy children. It is characterized by acute manifestation of recurrent seizures or refractory status epilepticus preceded by febrile illness, but without evidence of infectious encephalitis. To date, the absence of specific biomarkers poses a significant diagnostic challenge; nonetheless, early diagnosis is very important for optimal management. FIRES is mostly irreversible and its sequelae include drug-resistant epilepsy and neuropsychological impairments. The treatment of FIRES represents a significant challenge for clinicians and is associated with low success rates. Early introduction of ketogenic diet seems to represent the most effective and promising treatment. This review aims to highlight the most recent insights on clinical features, terminology, epidemiology, pathogenesis, diagnostic challenges and therapeutic options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.