ArticleScientific reports2019
Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na
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Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Human iPSC-cardiomyocyte-aggregate cell therapy in non-human primates and correlation of heart recovery with contractile and electrophysiological cardiomyocyte properties.Nature communications · 2026Article
- Consequences of Right Heart Disease for Cardiac Electrophysiology and Arrhythmias: Cellular and Structural Mechanisms.CJC open · 2025Review
- Article
- The Role of Human-Induced Pluripotent Stem Cells in Studying Cardiac Channelopathies.International journal of molecular sciences · 2024Review
- Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart.Nature cell biology · 2024Article
- Protein-free media for cardiac differentiation of hPSCs in 2000 mL suspension culture.Stem cell research & therapy · 2024Article
- Application and perspective of CRISPR/Cas9 genome editing technology in human diseases modeling and gene therapy.Frontiers in genetics · 2024Review
- Article
- Patient-specific iPSC-derived cardiomyocytes reveal aberrant activation of Wnt/β-catenin signaling in SCN5A-related Brugada syndrome.Stem cell research & therapy · 2023Article
- Functional Characterisation of the RareInternational journal of molecular sciences · 2023Article
- Heart in a dish - choosing the right in vitro model.Disease models & mechanisms · 2023Article
- HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity.BMC cardiovascular disorders · 2023Article
- Automated Patch-Clamp and Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Synergistic Approach in the Study of Brugada Syndrome.International journal of molecular sciences · 2023Review
- Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.Cardiovascular research · 2023Article
- iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development.Biomedicines · 2023Review
- Genome Editing and Inherited Cardiac Arrhythmias.Advances in experimental medicine and biology · 2023Article
- Diffuse fibrosis and repolarization disorders explain ventricular arrhythmias in Brugada syndrome: a computational study.Scientific reports · 2022Article
- Deconvoluting the Cells of the Human Heart with iPSC Technology: Cell Types, Protocols, and Uses.Current cardiology reports · 2022Review
- Progress in Bioengineering Strategies for Heart Regenerative Medicine.International journal of molecular sciences · 2022Review
- Deciphering Common Long QT Syndrome Using CRISPR/Cas9 in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Jeanne de la RocheInstitute for Neurophysiology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany. delaroche.jeanne@mh-hannover.de.ORCID http://orcid.org/0000-0001-5753-1732
Paweorn AngsutararuxSiriraj Center of Excellence for Stem Cell Research (SiSCR), Faculty of Medicine, Siriraj Hospital, 2, Bangkoknoi, Bangkok, 10700, Thailand.
Henning KempfDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Montira JananSiriraj Center of Excellence for Stem Cell Research (SiSCR), Faculty of Medicine, Siriraj Hospital, 2, Bangkoknoi, Bangkok, 10700, Thailand.
Emiliano BolesaniDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Stefan ThiemannInstitute for Neurophysiology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Daniel WojciechowskiInstitute for Neurophysiology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Michelle CoffeeDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Annika FrankeDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Kristin SchwankeDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Andreas LefflerDepartment of Anaesthesiology and Intensive Care, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Sudjit LuanpitpongSiriraj Center of Excellence for Stem Cell Research (SiSCR), Faculty of Medicine, Siriraj Hospital, 2, Bangkoknoi, Bangkok, 10700, Thailand.ORCID http://orcid.org/0000-0002-1639-4935
Surapol IssaragrisilSiriraj Center of Excellence for Stem Cell Research (SiSCR), Faculty of Medicine, Siriraj Hospital, 2, Bangkoknoi, Bangkok, 10700, Thailand. surapol.iss@mahidol.ac.th.
Martin FischerInstitute for Neurophysiology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.
Robert ZweigerdtDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery (HTTG), Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO) and Hans Borst Zentrum (HBZ), Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany. zweigerdt.robert@mh-hannover.de.ORCID http://orcid.org/0000-0002-4656-0770
Medizinische Hochschule Hannover · DESiriraj Hospital · THNovo Nordisk (Denmark) · DK
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss-of-function mutations of the SCN5A gene encoding for the sodium channel α-subunit Na
Indexed as
MutationAdultBrugada SyndromeCRISPR-Cas SystemsHEK293 CellsHumansInduced Pluripotent Stem CellsMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesNAV1.5 Voltage-Gated Sodium Channel
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.