ArticleScientific reports2019
Allostatic adaptation and personalized physiological trade-offs in the circadian regulation of the HPA axis: A mathematical modeling approach.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
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- A multiscale inflammatory map: linking individual stress to societal dysfunction.Frontiers in science · 2024Article
- Mathematical modeling of temperature-induced circadian rhythms.Frontiers in systems biology · 2024Article
- The Physiological and Pharmacological Significance of the Circadian Timing of the HPA Axis: A Mathematical Modeling Approach.Journal of pharmaceutical sciences · 2024Review
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence.Development and psychopathology · 2023Article
- The SCN-HPA-Periphery Circadian Timing System: Mathematical Modeling of Clock Synchronization and the Effects of Photoperiod on Jetlag Adaptation.Journal of biological rhythms · 2023Article
- Do diurnal salivary cortisol curves carry meaningful information about the regulatory biology of the HPA axis in healthy humans?Psychoneuroendocrinology · 2023Article
- Stressor-Induced Temporal Cortisol Deficiency as a Primary Trigger for Adaptation to Stress.International journal of environmental research and public health · 2022Article
- Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis.Frontiers in endocrinology · 2022Article
- Teaching computational systems biology with an eye on quantitative systems pharmacology at the undergraduate level: Why do it, who would take it, and what should we teach?Frontiers in systems biology · 2022Article
- Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change.Frontiers in endocrinology · 2022Article
- Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag.Scientific reports · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis orchestrates the physiological response to unpredictable acute stressors. Moreover, the HPA axis exhibits prominent circadian activity and synchronizes peripheral circadian clocks to daily environmental cycles, thereby promoting homeostasis. Persistent disruption of homeostatic glucocorticoid circadian rhythmicity due to chronic stress exposure is correlated with the incidence of various pathological conditions including depression, diabetes and cancer. Allostatic habituation of the HPA axis, such that glucocorticoid levels retain homeostatic levels upon chronic exposure to stress, can therefore confer fitness advantages by preventing the sustained dysregulation of glucocorticoid-responsive signaling pathways. However, such allostatic adaptation results in a physiological cost (allostatic load) that might impair the homeostatic stress-responsive and synchronizing functions of the HPA axis. We use mathematical modeling to characterize specific chronic stress-induced allostatic adaptations in the HPA network. We predict the existence of multiple individualized regulatory strategies enabling the maintenance of homeostatic glucocorticoid rhythms, while allowing for flexible HPA response characteristics. We show that this regulatory variability produces a trade-off between the stress-responsive and time-keeping properties of the HPA axis. Finally, allostatic regulatory adaptations are predicted to cause a time-of-day dependent sensitization of the acute stress response and impair the entrainability of the HPA axis.
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