Evidence map›Paper›PMID 31371761›Full record

ArticleScientific reports2019

(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.

Shicheng Guo, Jia Liu, Ting Jiang, Dungyang Lee, Rongsheng Wang, Xinpeng Zhou, Yehua Jin, Yi Shen, Yan Wang, Fengmin Bai and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Frontiers in immunology · 2026
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  6. A comprehensive review ofFrontiers in pharmacology · 2023
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  12. Biomedical reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Shicheng GuoCenter for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States, 54449.
Jia LiuDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Ting JiangDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Dungyang LeeDivision of Biostatistics, University of Texas School of Public Health, Houston, TX, USA.
Rongsheng WangDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Xinpeng ZhouDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Yehua JinDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Yi ShenDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Yan WangArthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, 200052, China.
Fengmin BaiDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Qin DingDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Grace WangWashington University, St. Louis, Missouri, 63130, USA.
Jianyong ZhangShenzhen Traditional Chinese Medicine Hospital and The fourth Clinical Medical College of Guangzhou University of Chinese Medicine. Fuhua Road, Shenzhen, Guangzhou, 518033, China.
Xiaodong ZhouUniversity of Texas Medical School at Houston, 6431 Fannin, MSB5.270, Houston, TX, 77030, USA.
Steven J SchrodiCenter for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, United States, 54449.
Dongyi HeDepartment of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China. dongyihe@medmail.com.cn.
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine · CNShanghai Innovative Research Center of Traditional Chinese Medicine · CNMarshfield Clinic · USGuangzhou University of Chinese Medicine · CNThe University of Texas Health Science Center at Houston · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tripterygium is a traditional Chinese medicine that has widely been used in the treatment of rheumatic disease. (5R)-5-hydroxytriptolide (LLDT-8) is an extracted compound from Tripterygium, which has been shown to have lower cytotoxicity and relatively higher immunosuppressive activity when compared to Tripterygium. However, our understanding of LLDT-8-induced epigenomic impact and overall regulatory changes in key cell types remains limited. Doing so will provide critically important mechanistic information about how LLDT-8 wields its immunosuppressive activity. The purpose of this study was to assess the effects of LLDT-8 on transcriptome including mRNAs and long non-coding RNA (lncRNAs) in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) by a custom genome-wide microarray assay. Significant differential expressed genes were validated by QPCR. Our work shows that 394 genes (281 down- and 113 up-regulated) were significantly differentially expressed in FLS responding to the treatment of LLDT-8. KEGG pathway analysis showed 20 pathways were significantly enriched and the most significantly enriched pathways were relevant to Immune reaction, including cytokine-cytokine receptor interaction (P = 4.61 × 10

Indexed as

Arthritis, RheumatoidCytokinesDiterpenesEpigenomicsFemaleFibroblastsGene Expression RegulationHumansImmunityImmunosuppressive AgentsMaleRNA, Long NoncodingSynoviocytes5-hydroxytriptolideCytokinesDiterpenesImmunosuppressive AgentsRNA, Long Noncoding

Identifiers

PMID31371761
PMCPMC6671973
OpenAlexW2965087743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.