Evidence map›Paper›PMID 31371720›Full record

ReviewNature reviews. Disease primers2019

Obsessive-compulsive disorder.

Dan J Stein, Daniel L C Costa, Christine Lochner, Euripedes C Miguel, Y C Janardhan Reddy, Roseli G Shavitt, Odile A van den Heuvel, H Blair Simpson

Erratum issued 2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 380 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
380citing papers in PubMed, 17 pooled it
62.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05331937 phase3recruitingnot on this mapstarted 2022, after this paper: background citation

Transcranial Magnetic Stimulation (TMS) for Patients With Exposure Therapy-resistant Obsessive-compulsive Disorder (OCD): TETRO - a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2022 to 2027Enrolled250Conditions1 Hz Real rTMS to the Pre-SMA, 1 Hz Sham rTMS to the Pre-SMAArmsrepetitive transcranial magnetic stimulation (rTMS)
NCT07031544 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy and Influencing Factors of Combined Anterior Limb of Internal Capsule and Nucleus Accumbens Deep Brain Stimulation in Treatment-Refractory Obsessive-Compulsive Disorder

TypeinterventionalSponsorShanghai Mental Health CenterRan2024 to 2027Enrolled60ConditionsObsessive - Compulsive DisorderArmsdeep brain stimulation
3 · Its place in the literature

Who cites it

380 citing papers in PubMed, 17 syntheses or guidelines pooled it, 749 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

320 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Dan J SteinDepartment of Psychiatry, University of Cape Town and SA MRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa. dan.stein@uct.ac.za.
Daniel L C CostaOCD Research Program, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Christine LochnerDepartment of Psychiatry, Stellenbosch University and SA MRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch, South Africa.
Euripedes C MiguelOCD Research Program, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Y C Janardhan ReddyDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Roseli G ShavittOCD Research Program, Instituto de Psiquiatria, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Odile A van den HeuvelDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
H Blair SimpsonDepartment of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRNational Institute of Mental Health and Neurosciences · INNew York State Psychiatric InstituteStellenbosch University · ZAUniversity of Cape Town · ZAVrije Universiteit Amsterdam · NL

Funding

Identifying Reproducible Brain Signatures of Obsessive-Compulsive ProfilesR01MH113250 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SIMPSON, HELEN BLAIR, WALL, MELANIE M · 2017 to 2021
$4.2M
NIMH NIH HHS R01 MH113250
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) is a highly prevalent and chronic condition that is associated with substantial global disability. OCD is the key example of the 'obsessive-compulsive and related disorders', a group of conditions which are now classified together in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the International Classification of Diseases, 11th Revision, and which are often underdiagnosed and undertreated. In addition, OCD is an important example of a neuropsychiatric disorder in which rigorous research on phenomenology, psychobiology, pharmacotherapy and psychotherapy has contributed to better recognition, assessment and outcomes. Although OCD is a relatively homogenous disorder with similar symptom dimensions globally, individualized assessment of symptoms, the degree of insight, and the extent of comorbidity is needed. Several neurobiological mechanisms underlying OCD have been identified, including specific brain circuits that underpin OCD. In addition, laboratory models have demonstrated how cellular and molecular dysfunction underpins repetitive stereotyped behaviours, and the genetic architecture of OCD is increasingly understood. Effective treatments for OCD include serotonin reuptake inhibitors and cognitive-behavioural therapy, and neurosurgery for those with intractable symptoms. Integration of global mental health and translational neuroscience approaches could further advance knowledge on OCD and improve clinical outcomes.

Indexed as

Cognitive Behavioral TherapyHumansObsessive-Compulsive DisorderPrevalencePsychometrics

Identifiers

PMID31371720
PMCPMC7370844
OpenAlexW2965887024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.