ArticleNature communications2019
Expansion of a core regulon by transposable elements promotes Arabidopsis chemical diversity and pathogen defense.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nearby transposable elements impact plant stress gene regulatory networks: a meta-analysis in A. thaliana and S. lycopersicum.BMC genomics · 2022Pooled it
- A retrotransposon insertion upstream of Arabidopsis thaliana CRK8 receptor-like kinase modulates a trade-off between pathogen defense and salt tolerance.The Plant journal : for cell and molecular biology · 2025Article
- Guns in rosettes: The Arabidopsis chemical weapons arsenal.Plant physiology · 2025Review
- WRKYs as regulatory hubs of secondary metabolic networks: Diverse inducers and distinct responses.Plant communications · 2025Review
- Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.Plant communications · 2025Review
- Neutral transcriptome rewiring promotes quantitative disease resistance evolvability at the species level.The Plant cell · 2025Article
- ANAC042 Regulates the Biosynthesis of Conserved- and Lineage-Specific Phytoalexins in Arabidopsis.International journal of molecular sciences · 2025Article
- Understanding the Regulation Activities of Transposons in Driving the Variation and Evolution of Polyploid Plant Genome.Plants (Basel, Switzerland) · 2025Review
- Advances in WRKY regulation of immune responses in medicinal plants.Frontiers in plant science · 2025Review
- Advances in the Involvement of Metals and Metalloids in Plant Defense Response to External Stress.Plants (Basel, Switzerland) · 2024Review
- The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion.Molecular biology and evolution · 2023Article
- Dynamic enhancer transcription associates with reprogramming of immune genes during pattern triggered immunity in Arabidopsis.BMC biology · 2022Article
- The R2R3 MYB Transcription FactorPlants (Basel, Switzerland) · 2022Article
- Cis-regulatory sequences in plants: Their importance, discovery, and future challenges.The Plant cell · 2022Review
- Review
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- LPMO-oxidized cellulose oligosaccharides evoke immunity in Arabidopsis conferring resistance towards necrotrophic fungus B. cinerea.Communications biology · 2021Article
- Genome-wide (ChIP-seq) identification of target genes regulated by WRKY33 during submergence stress in Arabidopsis.BMC genomic data · 2021Article
- The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase.Nature communications · 2021Article
- Mobility connects: transposable elements wire new transcriptional networks by transferring transcription factor binding motifs.Biochemical Society transactions · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plants synthesize numerous ecologically specialized, lineage-specific metabolites through biosynthetic gene duplication and functional specialization. However, it remains unclear how duplicated genes are wired into existing regulatory networks. We show that the duplicated gene CYP82C2 has been recruited into the WRKY33 regulon and indole-3-carbonylnitrile (ICN) biosynthetic pathway through exaptation of a retroduplicated LINE retrotransposon (EPCOT3) into an enhancer. The stepwise development of a chromatin-accessible WRKY33-binding site on EPCOT3 has potentiated the regulatory neofunctionalization of CYP82C2 and the evolution of inducible defense metabolite 4-hydroxy-ICN in Arabidopsis thaliana. Although transposable elements (TEs) have long been recognized to have the potential to rewire regulatory networks, these results establish a more complete understanding of how duplicated genes and TEs contribute in concert to chemical diversity and pathogen defense.
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