ArticleScience (New York, N.Y.)2019
Somatic evolution and global expansion of an ancient transmissible cancer lineage.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
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Who cites it
40 citing papers in PubMed.
- Article
- Comparative Genetics of Canine and Human Cancers.Veterinary sciences · 2025Review
- Mutation profile and chromosomal abnormality in adenomyosis.Reproduction (Cambridge, England) · 2025Article
- Article
- Canine Transmissible Venereal Tumor: Anatomical Locations, Chemotherapy Response, and Epidemiological Aspects at a Veterinary Teaching Hospital in Brazil (2012-2022).Animals : an open access journal from MDPI · 2025Article
- Horizontal transfer of nuclear DNA in transmissible cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolution of transmissible cancers: An adaptive, plastic strategy of selfish genetic elements?iScience · 2024Review
- Divergent DNA methylation patterns and gene expression in MYC andVeterinary world · 2024Article
- Marine transmissible cancer navigates urbanized waters, threatening spillover.Proceedings. Biological sciences · 2024Article
- Germline gene fusions across species reveal the chromosomal instability regions and cancer susceptibility.iScience · 2023Article
- Time-resolved, integrated analysis of clonally evolving genomes.PLoS genetics · 2023Article
- Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.Nature cancer · 2023Article
- Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia.Nature cancer · 2023Article
- Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians.Open biology · 2023Article
- Transmission of canine transmissible venereal tumour between two dogs in the UK.The Journal of small animal practice · 2023Article
- The evolution of two transmissible cancers in Tasmanian devils.Science (New York, N.Y.) · 2023Article
- Is chimerism associated with cancer across the tree of life?PloS one · 2023Article
- Immunophenotypic and molecular profile of cancer stem-cell markers in ex vivo canine transmissible venereal tumour (CTVT).Veterinary medicine and science · 2022Article
- Sex disparity in oronasal presentations of canine transmissible venereal tumour.The Veterinary record · 2022Article
- The foundational framework of tumors: Gametogenesis, p53, and cancer.Seminars in cancer biology · 2022Review
Corrections and comments
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Authors and funding
80 authors.
Adrian Baez-OrtegaTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9201-4420
Kevin Gori *Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7975-4275
Andrea Strakova *Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6221-5515
Janice L AllenAnimal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
Karen M AllumWorld Vets, Gig Harbor, USA.
Leontine Bansse-IssaAnimal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
Thinlay N BhutiaSikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India.
Jocelyn L BissonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5337-1807
Cristóbal BriceñoConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.ORCID 0000-0001-8999-650X
Artemio Castillo DomrachevaCorozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.
Anne M CorriganSt. George's University, True Blue, Grenada.
Hugh R CranThe Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
Jane T CrawfordAnimal Medical Centre, Belize City, Belize.
Eric DavisInternational Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA.ORCID 0000-0002-2281-8941
Karina F de CastroCentro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.
Andrigo B de NardiDepartment of Clinical and Veterinary Surgery, São Paulo State University (UNESP), São Paulo, Brazil.ORCID 0000-0001-6463-2144
Anna P de VosLadybrand Animal Clinic, Ladybrand, South Africa.
Laura Delgadillo KeenanVeterinary Clinic Sr. Dog's, Guadalajara, Mexico.
Edward M DonelanAnimal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.ORCID 0000-0001-8035-3057
Adela R Espinoza HuertaWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.ORCID 0000-0003-0458-8131
Ibikunle A FaramadeNational Veterinary Research Institute, Vom, Nigeria.
Mohammed FazilAnimal Clinic, Mombasa, Kenya.ORCID 0000-0002-3114-9022
Eleni FotopoulouIntermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.
Skye N FrueanAnimal Protection Society of Samoa, Apia, Samoa.
Fanny Gallardo-ArrietaFaculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
Olga GlebovaVeterinary Clinic BIOCONTROL, Moscow, Russia.
Pagona G GouletsouFaculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.ORCID 0000-0001-5399-0528
Rodrigo F Häfelin ManriqueVeterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.
Joaquim J G P HenriquesOnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.ORCID 0000-0002-2293-2277
Rodrigo S HortaUniversidade Vila Velha, Vila Velha, Brazil.
Natalia IgnatenkoVeterinary Clinic Zoovetservis, Kiev, Ukraine.
Yaghouba KaneÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.
Cathy KingWorld Vets, Gig Harbor, USA.
Debbie KoenigWorld Vets, Gig Harbor, USA.
Ada KrupaDepartment of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Steven J KruzeniskiWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.
Young-Mi KwonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Marta Lanza-PereaSt. George's University, True Blue, Grenada.
Mihran LazyanVetexpert Veterinary Group, Yerevan, Armenia.
Adriana M Lopez QuintanaVeterinary Clinic Lopez Quintana, Maldonado, Uruguay.ORCID 0000-0003-0989-3397
Thibault LosfeltClinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.
Gabriele MarinoDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Simón Martínez CastañedaFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.ORCID 0000-0002-8727-0307
Mayra F Martínez-LópezSchool of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.ORCID 0000-0001-9149-3960
Michael MeyerTouray & Meyer Vet Clinic, Serrekunda, The Gambia.
Edward J MignecoHillside Animal Hospital, St. Louis, MO, USA.
Berna NakanwagiThe Kampala Veterinary Surgery, Kampala, Uganda.
Karter B NealAsavet Veterinary Charities, Tucson, AZ, USA.
Winifred NeunzigWorld Vets, Gig Harbor, USA.
Máire Ní LeathlobhairTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8523-4935
Sally J NixonVets Beyond Borders, Bylakuppe, India.
Antonio Ortega-PachecoFaculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.ORCID 0000-0002-8502-8023
Francisco Pedraza-OrdoñezLaboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.ORCID 0000-0002-3217-8941
Maria C PeleteiroInterdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
Katherine PolakFour Paws International, Vienna, Austria.
Ruth J PyeVets Beyond Borders, The Rocks, Australia.ORCID 0000-0002-1001-3329
John F ReeceHelp in Suffering, Jaipur, India.
Jose Rojas GutierrezVeterinary Clinic Dr José Rojas, Los Andes, Chile.
Haleema SadiaDepartment of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
Sheila K SchmelingCorozal Veterinary Clinic, Corozal Town, Belize.ORCID 0000-0003-3828-9818
Olga ShamanovaVeterinary Clinic Vetmaster, Ramenskoye, Russia.
Alan G SherlockVets Beyond Borders, The Rocks, Australia.
Maximilian StammnitzTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1704-9199
Audrey E Steenland-SmitAnimal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
Alla SvitichState Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.
Lester J Tapia MartínezWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.
Ismail Thoya NgokaJomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Cristian G TorresLaboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.ORCID 0000-0003-0019-2404
Elizabeth M TudorFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.
Mirjam G van der WelAnimal Anti Cruelty League, Port Elizabeth, South Africa.
Bogdan A ViţălaruClinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.
Sevil A VuralDepartment of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.ORCID 0000-0003-2111-3381
Oliver WalkintonVets Beyond Borders, The Rocks, Australia.
Jinhong WangTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0809-9856
Alvaro S Wehrle-MartinezFaculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
Sophie A E WiddowsonLilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.
Michael R StrattonWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-6035-153X
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3596-4515
Iñigo MartincorenaWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-1122-4416
Elizabeth P MurchisonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.ORCID 0000-0001-7462-8907
Funding
Cancer Research UK 21777Wellcome Trust 102942Wellcome Trust 102942/Z/13/A
Abstract
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.
Indexed as
AnimalsClonal EvolutionDog DiseasesDogsExosomesGene ExpressionMutagenesisPhylogenySelection, GeneticVenereal Tumors, Veterinary
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