ArticleScience (New York, N.Y.)2019
Identification of a T follicular helper cell subset that drives anaphylactic IgE.
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In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 280 papers.
0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed
30.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
280 citing papers in PubMed, 458 citations in OpenAlex.
- Clinical and immunological outcomes after randomized trial of baked milk oral immunotherapy for milk allergy.JCI insight · 2025Trial
- CD8Nature communications · 2022Trial
- Oral desensitization therapy for peanut allergy induces dynamic changes in peanut-specific immune responses.Allergy · 2022Trial
- Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts.The Journal of allergy and clinical immunology · 2022Trial
- Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells.The Journal of clinical investigation · 2022Trial
- Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children.The Journal of allergy and clinical immunology · 2021Trial
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Review
- Article
- Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026Article
- Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance.Science translational medicine · 2026Article
- From Diet to Dysbiosis: How Nutritional Factors Shape Gut Microbiota and Drive Airway Inflammation in Pediatric Asthma.Nutrients · 2026Review
- The Food Allergy-Eosinophilic Esophagitis Continuum: Implications for Food Allergy Immunotherapy.The journal of allergy and clinical immunology. In practice · 2026Review
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation.Immunity · 2026Article
- Article
- Breaking the bottleneck of asthma treatment: the future of omni-targeted therapy.Journal of advanced research · 2026Review
- Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice.Nature microbiology · 2026Article
- IgE Production Beyond Classical T-Cell Help.Immune network · 2026Review
220 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Uthaman GowthamanDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-5484-7851
Jennifer S Chen *Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-7808-2670
Biyan Zhang *Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-0329-2451
William F FlynnThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.ORCID 0000-0001-6533-0340
Yisi LuDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-7960-5445
Wenzhi SongDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Julie JosephDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Jake A GertieDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-3867-1884
Lan XuDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-9909-7660
Magalie A ColletThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.ORCID 0000-0002-7200-345X
Jessica D S GrassmannThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.ORCID 0000-0001-9076-452X
Tregony SimoneauThe Asthma Center, CT Children's Medical Center, Hartford, CT 06106, USA.ORCID 0000-0003-2407-4402
David ChiangJaffe Food Allergy Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3844-6126
M Cecilia BerinJaffe Food Allergy Institute and Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-9051-9249
Joseph E CraftDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-1368-6756
Jason S WeinsteinCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA.
Adam Williams *The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. stephanie.eisenbarth@yale.edu adam.williams@jax.org.ORCID 0000-0002-5151-4103
Stephanie C Eisenbarth *Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. stephanie.eisenbarth@yale.edu adam.williams@jax.org.ORCID 0000-0002-1244-208X
Yale University · USJackson Laboratory · USIcahn School of Medicine at Mount Sinai · USConnecticut Children's Medical Center · USRutgers, The State University of New Jersey · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MIMMUNE RESPONSES IN LUPUSR37AR040072 · NIAMS · YALE UNIVERSITY · PI CRAFT, JOSEPH EDGAR · 2000 to 2025
$7.4MImmune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1MRegulation of adaptive immunity by the NOD-like receptor NLRP10R01AI108829 · NIAID · YALE UNIVERSITY · PI EISENBARTH, STEPHANIE CAROLINE · 2014 to 2018
$2.1MThe Function of lncRNAs in Airway Epithelial CellsR21AI133440 · NIAID · JACKSON LABORATORY · PI WILLIAMS, ADAM · 2018 to 2019
$520kThe Role of the lncRNA MORRBID in Controlling Dendritic Cell Lifespan and Adaptive ImmunityR21AI135221 · NIAID · JACKSON LABORATORY · PI WILLIAMS, ADAM · 2018 to 2019
$520kNCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI108829NIAID NIH HHS R01 AI136942NIAID NIH HHS R21 AI133440NIAID NIH HHS R21 AI135221NIAMS NIH HHS R37 AR040072
Abstract
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly understood. T follicular helper (T
Indexed as
AdolescentAnaphylaxisAnimalsChildGATA3 Transcription FactorGuanine Nucleotide Exchange FactorsHumansImmunoglobulin EInterleukin-13MiceMice, Inbred C57BLMice, Mutant StrainsProto-Oncogene Proteins c-bcl-6T-Lymphocytes, Helper-InducerDock8 protein, mouseGATA3 Transcription FactorGuanine Nucleotide Exchange FactorsImmunoglobulin EInterleukin-13Proto-Oncogene Proteins c-bcl-6
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.