Evidence map›Paper›PMID 31371510›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic.

Francesco Tadini-Buoninsegni, Stine A Mikkelsen, Louise S Mogensen, Robert S Molday, Jens Peter Andersen

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Membrane Surface Charge, Phospholipids, and Protein Localization.Reviews of physiology, biochemistry and pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Francesco Tadini-BuoninsegniDepartment of Chemistry Ugo Schiff, University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-5594-2554
Stine A MikkelsenDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark.
Louise S MogensenDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark.
Robert S MoldayDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Jens Peter AndersenDepartment of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark; jpa@biomed.au.dk.ORCID 0000-0003-0654-4300
Aarhus University · DKUniversity of British Columbia · CAUniversity of Florence · IT

Funding

CIHR PJT148649
6 · The paper itself

Abstract

Phospholipid flippases (P4-ATPases) utilize ATP to translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes, thus generating and maintaining transmembrane lipid asymmetry essential for a variety of cellular processes. P4-ATPases belong to the P-type ATPase protein family, which also encompasses the ion transporting P2-ATPases: Ca

Indexed as

Adenosine TriphosphatasesAdenosine TriphosphateAnimalsBiological TransportCalcium-Transporting ATPasesCation Transport ProteinsCell MembraneCerebellar AtaxiaCytoplasmElectrophysiological PhenomenaH(+)-K(+)-Exchanging ATPaseHumansIntellectual DisabilityMembrane LipidsMutationPhosphatidylethanolaminesAdenosine TriphosphatasesAdenosine TriphosphateATP8A2 protein, humanCalcium-Transporting ATPasesCation Transport ProteinsH(+)-K(+)-Exchanging ATPaseMembrane LipidsphosphatidylethanolaminePhosphatidylethanolaminesPhosphatidylserinesPhospholipidsPhospholipid Transfer Proteinssodium-translocating ATPaseCAMRQ syndromecharge displacementflippasephospholipid transportSSM method

Identifiers

PMID31371510
PMCPMC6697784
OpenAlexW2965242683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.