Evidence map›Paper›PMID 31371407›Full record

ArticleGenetics2019

Adaptation by Loss of Heterozygosity in

Timothy Y James, Lucas A Michelotti, Alexander D Glasco, Rebecca A Clemons, Robert A Powers, Ellen S James, D Rabern Simmons, Fengyan Bai, Shuhua Ge

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
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  9. Genomic analyses reveal high diversity and rapid evolution ofAntimicrobial agents and chemotherapy · 2025
    Article
  10. Review
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  12. Article
  13. Article
  14. Article
  15. Review
  16. Loss of Heterozygosity and Its Importance in Evolution.Journal of molecular evolution · 2023
    Review
  17. Stage-specific transposon activity in the life cycle of the fairy-ring mushroomProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Timothy Y JamesDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109 tyjames@umich.edu.ORCID 0000-0002-1123-5986
Lucas A MichelottiDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
Alexander D GlascoDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
Rebecca A ClemonsDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
Robert A PowersDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.ORCID 0000-0002-5429-4548
Ellen S JamesDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
D Rabern SimmonsDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109.
Fengyan BaiInstitute of Microbiology, Chinese Academy of Sciences, State Key Laboratory of Mycology, Chaoyang District, Beijing 100101, China.
Shuhua GeTechnology Development and Transfer Center, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing 100029, China.
University of Michigan–Ann Arbor · USChinese Academy of Sciences · CN

Funding

How eukaryotic pathogens explore the fitness landscape by mitotic recombinationR21AI105167 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES, TIM · 2013 to 2014
$428k
NIAID NIH HHS R21 AI105167
6 · The paper itself

Abstract

Loss of heterozygosity (LOH) is observed during vegetative growth and reproduction of diploid genotypes through mitotic crossovers, aneuploidy caused by nondisjunction, and gene conversion. We aimed to test the role that LOH plays during adaptation of two highly heterozygous

Indexed as

Adaptation, PhysiologicalAllelesAneuploidyChromosomes, FungalClonal EvolutionDiploidyDNA RepairGene ConversionHeterozygoteLoss of HeterozygosityRecombination, GeneticSaccharomyces cerevisiaeexperimental evolutiongene conversionmitotic recombinationresequencingSaccharomyces cerevisiae

Identifiers

PMID31371407
PMCPMC6781901
OpenAlexW2965046778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.