Evidence map›Paper›PMID 31371298›Full record

Observational studyBMJ open2019

Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort.

Sarah E Keuss, Thomas D Parker, Christopher A Lane, Chandrashekar Hoskote, Sachit Shah, David M Cash, Ashvini Keshavan, Sarah M Buchanan, Heidi Murray-Smith, Andrew Wong and 10 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. High-Resolution MRA Cerebrovascular Findings in a Tri-Ethnic Population.AJNR. American journal of neuroradiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Prevalence of incidental brain MRI findings of clinical relevance in a diverse Hispanic/Latino population.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
    Article
  10. Incidental unilateral idiopathic maculopathy in children.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Sarah E KeussDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-7403-281X
Thomas D ParkerDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Christopher A LaneDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Chandrashekar HoskoteLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, London, UK.
Sachit ShahLysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, London, UK.
David M CashDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Sarah M BuchananDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Heidi Murray-SmithDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Sarah-Naomi JamesMRC Unit for Lifelong Health and Ageing, University College London, London, UK.ORCID 0000-0002-3800-4416
Kirsty LuDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Jessica CollinsDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Daniel G BeasleySchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID 0000-0003-1433-9016
Ian B MaloneDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
David L ThomasLeonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, London, UK.
Anna BarnesInstitute of Nuclear Medicine, University College London Hospitals, London, UK.
Marcus RichardsMRC Unit for Lifelong Health and Ageing, University College London, London, UK.
Nick FoxDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Jonathan M SchottDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
UK Dementia Research Institute · GBMRC Unit for Lifelong Health and Ageing · GBNational Hospital for Neurology and Neurosurgery · GBKing's College London · GBRoyal London Hospital · GB

Funding

Medical Research Council CSUB19166Medical Research Council MC_UU_00019/3Medical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/3Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Wellcome TrustWellcome Trust 200,109/Z/15/Z
6 · The paper itself

Abstract

objectiveTo summarise the incidental findings detected on brain imaging and blood tests during the first wave of data collection for the Insight 46 study.

designProspective observational sub-study of a birth cohort.

settingSingle-day assessment at a research centre in London, UK.

participants502 individuals were recruited from the MRC National Survey of Health and Development (NSHD), the 1946 British birth cohort, based on pre-specified eligibility criteria; mean age was 70.7 (SD: 0.7) and 49% were female. OUTCOME MEASURES: Data regarding the number and types of incidental findings were summarised as counts and percentages, and 95% confidence intervals were calculated.

results93.8% of participants completed a brain scan (n=471); 4.5% of scanned participants had a pre-defined reportable abnormality on brain MRI (n=21); suspected vascular malformations and suspected intracranial mass lesions were present in 1.9% (n=9) and 1.5% (n=7) respectively; suspected cerebral aneurysms were the single most common vascular abnormality, affecting 1.1% of participants (n=5), and suspected meningiomas were the most common intracranial lesion, affecting 0.6% of participants (n=3); 34.6% of participants had at least one abnormality on clinical blood tests (n=169), but few reached the prespecified threshold for urgent action (n=11).

conclusionsIn older adults, aged 69-71 years, potentially serious brain MRI findings were detected in around 5% of participants, and clinical blood test abnormalities were present in around one third of participants. Knowledge of the expected prevalence of incidental findings in the general population at this age is useful in both research and clinical settings.

Indexed as

Hematologic TestsIncidental FindingsMagnetic Resonance ImagingAgedBrainBrain DiseasesFemaleHumansLondonMaleNeuroimagingPrevalenceProspective Studiesepidemiologyinternal medicinemedical ethicsneurology

Identifiers

PMID31371298
PMCPMC6678011
OpenAlexW2966193304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.