Evidence map›Paper›PMID 31371122›Full record

ReviewPediatric neurology2020

Pediatric Stroke: Unique Implications of the Immature Brain on Injury and Recovery.

Laura A Malone, Ryan J Felling

Abstract readReview
In one paragraph

Review in Pediatric neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Implications of age at lesion onset for neuropsychological outcomes: A systematic review focusing on focal brain lesions.Cortex; a journal devoted to the study of the nervous system and behavior · 2023
    Pooled it
  2. Guideline
  3. Article
  4. Isolated infratentorial involvement in a case of Parry Romberg syndrome without neurological dysfunction.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Non-routine thrombectomy in pediatric arterial ischemic stroke.Diagnostic and interventional radiology (Ankara, Turkey) · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  13. Review
  14. Grand challenges in pediatric stroke.Frontiers in stroke · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura A MaloneJohns Hopkins University School of Medicine, Department of Neurology, Baltimore, Maryland. Electronic address: lmalone3@jhmi.edu.
Ryan J FellingJohns Hopkins University School of Medicine, Department of Neurology, Baltimore, Maryland.

Funding

Epigenetic regulation of neurogenesis following perinatal hypoxic-ischemic brain injuryK08NS097704 · NINDS · JOHNS HOPKINS UNIVERSITY · PI FELLING, RYAN J · 2017 to 2021
$999k
NINDS NIH HHS K08 NS097704
6 · The paper itself

Abstract

Pediatric stroke causes significant morbidity for children resulting in lifelong neurological disability. Although hyperacute recanalization therapies are available for pediatric patients, most patients are ineligible for these treatments. Therefore the mainstay for pediatric stroke treatment relies on rehabilitation to improve outcomes. Little is known about the ideal rehabilitation therapies for pediatric patients with stroke and the unique interplay between the developing brain and our models of stroke recovery. In this review, we first discuss the consequences of pediatric stroke. Second, we examine the scientific evidence that exists between the mechanisms of recovery and how they are different in the pediatric developing brain. Finally, we evaluate potential interventions that could improve outcomes.

Indexed as

Child DevelopmentNerve NetNeurogenesisNeuronal PlasticityRecovery of FunctionStrokeStroke RehabilitationAdolescentChildChild, PreschoolHumansInfantInfant, NewbornBrain injuryNeural recoveryNeurorehabilitationPediatric stroke

Identifiers

PMID31371122
PMCPMC6959511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.