Evidence map›Paper›PMID 31370977›Full record

ArticleJournal of substance abuse treatment2019

A comparison of buprenorphine and psychosocial treatment outcomes in psychosocial and medical settings.

Ned J Presnall, D A Patterson Silver Wolf, Derek S Brown, Sara Beeler-Stinn, Richard A Grucza

Abstract readComparative Study
In one paragraph

Article in Journal of substance abuse treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ned J PresnallBrown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130, United States of America; Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St. Louis, MO 63110, United States of America. Electronic address: npresnall@wustl.edu.
D A Patterson Silver WolfBrown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130, United States of America. Electronic address: dpatterson22@wustl.edu.
Derek S BrownBrown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130, United States of America. Electronic address: dereksbrown@wustl.edu.
Sara Beeler-StinnBrown School of Social Work, Washington University, One Brookings Drive, St. Louis, MO 63130, United States of America. Electronic address: sbeeler@wustl.edu.
Richard A GruczaDepartment of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St. Louis, MO 63110, United States of America. Electronic address: rick@wustl.edu.

Funding

Transdisciplinary Training in Addictions ResearchT32DA015035 · NIDA · WASHINGTON UNIVERSITY · PI Leopoldo J Cabassa, Patricia A Cavazos-Rehg · 2002 to 2026
$5.3M
AN EXAMINATION OF AGE-RELATED DISPARITIES IN MEDICATION ASSISTED TREATMENT AND ASSOCIATED OUTCOMESR21DA044744 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2017 to 2018
$419k
NIDA NIH HHS R21 DA044744NIDA NIH HHS T32 DA015035
6 · The paper itself

Abstract

backgroundFacing an epidemic of opioid-related mortality, many government health departments, insurers, and treatment providers have attempted to expand patient access to buprenorphine in psychosocial substance use disorder (SUD) programs and medical settings.

methodsWith Missouri Medicaid data from 2008 to 2015, we used Cox proportional hazard models to estimate the relative hazards for treatment attrition and SUD-related emergency department (ED) visits or hospitalizations associated with buprenorphine in psychosocial SUD programs and medical settings. We also tested the association of buprenorphine with hours of psychosocial treatment during the first 30 days of psychosocial SUD treatment. The analytic sample included claims from 7606 individuals with an OUD diagnosis.

resultsCompared to psychosocial treatment without buprenorphine (PSY), the addition of buprenorphine (PSY-B) was associated with a significantly reduced hazard for treatment attrition (adjusted hazard ratio: 0.67, 95% CI: 0.62-0.71). Among buprenorphine episodes, office-based (B-OBOT), outpatient hospital (B-OPH), and no documented setting (B-PHA) were associated with reduced hazards for treatment attrition when compared to the psychosocial SUD setting (B-PSY) (adjusted hazard ratios: 0.27, 95% CI: 0.24-0.31; 0.46, 95% CI: 0.39-0.54; 0.70, 95% CI: 0.61-0.81). Compared to B-PSY, B-OBOT and B-PHA were associated with significantly reduced hazards for a SUD-related ED visits or hospitalization (adjusted hazard ratios: 0.59, 95% CI: 0.41-0.85; 0.53, 95% CI: 0.36-0.78). There was no significant difference between B-PSY and B-OPH or B-PSY and PSY in hazard for an SUD-related ED visit or hospitalization.

conclusionsOur findings support the conclusion that adding buprenorphine to Medicaid-covered psychosocial SUD treatment reduces patient attrition and SUD-related ED visits or hospitalizations but that buprenorphine treatment in office-based medical settings is even more effective in reducing these negative outcomes. Policy-makers should consider ways to expand buprenorphine access in all settings, but particularly in office-based medical settings. Buprenorphine treatment in an unbilled setting was associated with an increased hazard for patient attrition when compared to treatment in billed medical settings, indicating the importance of Medicaid-covered provider visits for patient retention.

Indexed as

Opioid-Related DisordersPsychotherapyAdultAmbulatory CareAnalgesics, OpioidBuprenorphineCombined Modality TherapyEmergency Service, HospitalFemaleHospitalizationHumansMaleMedicaidMiddle AgedMissouriOpiate Substitution TreatmentAnalgesics, OpioidBuprenorphineBuprenorphineIntensive outpatientMedicaidOBOTOffice-based opioid therapyOpioid use disorderOUDPharmacotherapyPrimary carePsychosocial

Identifiers

PMID31370977
PMCPMC7075557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.