Trial reportDevelopment and psychopathology2019
Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.
Trial report in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Foster Care Leads to Lower Irritability Among Adolescents with a History of Early Psychosocial Deprivation.Research on child and adolescent psychopathology · 2024Trial
- Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept.Developmental psychobiology · 2021Trial
- Discrete components of stress impact trajectories of childhood irritability but not adolescent mental health outcomes.JCPP advances · 2026Article
- Combined prenatal exposure to airborne polycyclic aromatic hydrocarbons and maternal distress is associated with childhood irritability.Frontiers in public health · 2026Article
- Irritability in autism examined through network analysis of phenotypic and physiological correlates.Scientific reports · 2025Article
- Article
- How will developmental neuroimaging contribute to the prediction of neurodevelopmental or psychiatric disorders? Challenges and opportunities.Developmental cognitive neuroscience · 2025Article
- Pediatric clinicians' perspectives on assessing concerns about young children's social-emotional wellbeing in primary care.Journal of child health care : for professionals working with children in the hospital and community · 2024Article
- An Equity-Focused Assessment of Evidence-Based Parenting Intervention Research.Clinical child and family psychology review · 2024Review
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
- Engaging primary care clinicians in the selection of implementation strategies for toddler social-emotional health promotion in community health centers.Families, systems & health : the journal of collaborative family healthcare · 2024Article
- Advancing earlier transdiagnostic identification of mental health risk: A pragmatic approach at the transition to toddlerhood.International journal of methods in psychiatric research · 2023Article
- Joint Consideration of Inhibitory Control and Irritability in Young Children: Contributions to Emergent Psychopathology.Research on child and adolescent psychopathology · 2022Article
- Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.Journal of psychopathology and clinical science · 2022Article
- Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.Development and psychopathology · 2021Article
- Preventing Irritability and Temper Outbursts in Youth by Building Resilience.Child and adolescent psychiatric clinics of North America · 2021Review
- Relations Between Child Temperament and Adolescent Negative Urgency in a High-Risk Sample.Journal of research in personality · 2021Article
- The significance of early parent-child attachment for emerging regulation: A longitudinal investigation of processes and mechanisms from toddler age to preadolescence.Developmental psychology · 2020Article
- Mapping infant neurodevelopmental precursors of mental disorders: How synthetic cohorts & computational approaches can be used to enhance prediction of early childhood psychopathology.Behaviour research and therapy · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Building on prior work using Tom Dishion's Family Check-Up, the current article examined intervention effects on dysregulated irritability in early childhood. Dysregulated irritability, defined as reactive and intense response to frustration, and prolonged angry mood, is an ideal marker of neurodevelopmental vulnerability to later psychopathology because it is a transdiagnostic indicator of decrements in self-regulation that are measurable in the first years of life that have lifelong implications for health and disease. This study is perhaps the first randomized trial to examine the direct effects of an evidence- and family-based intervention, the Family Check-Up (FCU), on irritability in early childhood and the effects of reductions in irritability on later risk of child internalizing and externalizing symptomatology. Data from the geographically and sociodemographically diverse multisite Early Steps randomized prevention trial were used. Path modeling revealed intervention effects on irritability at age 4, which predicted lower externalizing and internalizing symptoms at age 10.5. Results indicate that family-based programs initiated in early childhood can reduce early childhood irritability and later risk for psychopathology. This holds promise for earlier identification and prevention approaches that target transdiagnostic pathways. Implications for future basic and prevention research are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.