ArticleCritical care (London, England)2019
Vitamin A deficiency in critically ill children with sepsis.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03598127 (Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Prevalence and clinical impact of Vitamin A Deficiency (VAD) in critically ill children with sepsis.BMC pediatrics · 2025Article
- Vitamin C improves 28-day survival in patients with sepsis-associated acute kidney injury in the intensive care unit: a retrospective study.Frontiers in nutrition · 2025Article
- Association of vitamin A and D deficiency and the presence of sepsis in the geriatric population: a cross-sectional study.Frontiers in nutrition · 2025Article
- Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review.Frontiers in pharmacology · 2025Review
- Trends and projections of the disease burden of vitamin A deficiency in China from 1990 to 2021.Frontiers in nutrition · 2025Article
- A randomized controlled trial on the efficacy and safety of vitamin A supplementation in children with sepsis.Frontiers in pediatrics · 2025Article
- The association between serum vitamin A concentrations and virus hepatitis among U.S. adults from the NHANES database: a cross-sectional study.Frontiers in nutrition · 2024Article
- Vitamin A is associated with all-cause mortality in patients with chronic kidney disease: a population-based cohort study.Frontiers in nutrition · 2024Article
- Causal effects of genetically vitamins and sepsis risk: a two-sample Mendelian randomization study.BMC infectious diseases · 2023Article
- Article
- Plasma Retinol Concentrations and Dietary Intakes of Mother-Infant Sets in Singleton versus Twin Pregnancy.Nutrients · 2023Article
- Biomarkers of Micronutrients and Phytonutrients and Their Application in Epidemiological Studies.Nutrients · 2023Review
- Oxygen therapy for sepsis and prevention of complications.Acute and critical care · 2022Article
- Association of lower vitamin a levels in neonates and their mothers with increased risk of neonatal late-onset sepsis: A case-control study.Journal of mother and child · 2022Article
- Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection.International journal of environmental research and public health · 2022Review
- Low Levels of Few Micronutrients May Impact COVID-19 Disease Progression: An Observational Study on the First Wave.Metabolites · 2021Article
- Is Vitamin A Supplementation Associated With Anemia in Children Under 5 Years of Age in Peru: Secondary Analysis of the "Demographic Health Survey" 2015-2018?Global pediatric health · 2021Article
- Micronutrient status during paediatric critical illness: A scoping review.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice.PLoS neglected tropical diseases · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundData that indicate vitamin A status in critically ill children with sepsis are sparse. The association between serum vitamin A levels and the clinical outcomes of sepsis has not been well assessed. The aim of this study was to assess the prevalence of vitamin A deficiency in critically ill children with sepsis and its association with clinical outcomes.
methodsCritically ill children with sepsis admitted to the pediatric intensive care unit were engaged in this prospective study. Sex- and age-matched approximate-health children from the Department of Pediatric Surgery were enrolled as the control group. Blood samples were collected from all patients in the first 24 h of admission for the measurement of serum vitamin A status. We compared vitamin A status between the sepsis group and the control group. In addition, we compared the clinical characteristics of the two subgroups of septic patients with vitamin A deficiency and those without vitamin A deficiency. Univariate and multivariable methods were used to evaluate the association between vitamin A deficiency and septic shock.
resultsOne hundred sixty septic children and 49 approximate-health children were enrolled in this study. Vitamin A deficiency was found in 94 (58.8%) subjects in the study group and 6 (12.2%) subjects in the control group (P < 0.001). In septic patients, 28-day mortality and hospital mortality in patients with vitamin A deficiency were not significantly higher than that in patients without vitamin A deficiency (P > 0.05). However, vitamin A levels were inversely associated with higher PRISM scores in septic children with VAD (r = - 0.260, P = 0.012). Vitamin A deficiency was associated with septic shock with an unadjusted odds ratio (OR) of 3.297 (95% confidence interval (CI), 1.169 to 9.300; P = 0.024). In a logistic model, vitamin A deficiency (OR, 4.630; 95% CI, 1.027-20.866; P = 0.046), procalcitonin (OR, 1.029; 95% CI, 1.009-1.048; P = 0.003), and the Pediatric Risk of Mortality scores (OR, 1.132; 95% CI, 1.009-1.228; P = 0.003) were independently associated with septic shock.
conclusionThe prevalence of vitamin A deficiency was high in children with sepsis. Vitamin A deficiency may be a marker of mortality in critically ill children with sepsis.
trial registrationClinicaltrials.gov , NCT03598127.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.