ReviewTechnology in cancer research & treatment2019
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer.
Review in Technology in cancer research & treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
234 citing papers in PubMed, 2 syntheses or guidelines pooled it, 387 citations in OpenAlex.
- A systematic review and meta-analysis reveals enrichment of pro-inflammatory and bacterial immunity-modulating taxa in oral squamous cell carcinoma.Frontiers in immunology · 2026Pooled it
- Comparative analysis of bacterial abundance and diversity in tumour tissue of oral squamous cell carcinoma and non-tumour tissue: insights from a systematic review of 16S ribosomal RNA sequencing.BMC oral health · 2025Pooled it
- Randomized, Double-Blind, Placebo-Controlled Trial of the Probiotic Lactiplantibacillus plantarum Probio87 for Gut-Vaginal Microbiota Modulation in Healthy Women.Molecular nutrition & food research · 2026Trial
- Analysis of Intervention Effect and Satisfaction of Holistic Nursing after Oral Tumor Resection.Computational and mathematical methods in medicine · 2022Trial
- Impact of alcohol on gut microbial metabolism and the gut-liver-brain axis.Alcohol (Fayetteville, N.Y.) · 2026Review
- The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential.Cancer cell international · 2026Review
- Review
- The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis.Clinical and experimental dental research · 2026Review
- Intratumoral microbiota in cancer: molecular mechanism and therapeutic strategies.Molecular biomedicine · 2026Review
- Comparative microbiome profiling of betel quid chewers and non-chewers to identify dysbiotic microbial signatures.Scientific reports · 2026Article
- Decoding and exploiting intratumoral microbiota: from microenvironment modulation to clinical intervention.Molecular biology reports · 2026Review
- Emerging Therapeutic Strategies in Oral Cancer: Epigenetic, Mitochondrial and Immunotherapy Approaches.Journal of cellular and molecular medicine · 2026Review
- Prognostic significance of programmed death-ligand 1 expression in betel nut chewing patients with oral squamous cell carcinoma.BMC oral health · 2026Article
- Proteomics of Periodontitis-Associated Bacteria and Its Link to Oral Squamous Cell Carcinoma: A Contemporaneous Review.International dental journal · 2026Review
- Recent Research on the Role ofNutrients · 2026Review
- The Oral Microbiota: Implications in Mucosal Health and Systemic Disease-Crosstalk with Gut and Brain.Cells · 2026Review
- Oral and fecal microbiota in oral lichen planus and xerostomia patients: A preliminary study.Journal of dental sciences · 2026Article
- Lesion-specific oral microbiome signatures and predicted carcinogenic pathways in oral squamous cell carcinoma: a paired-site study in Pakistan.Journal of oral microbiology · 2026Article
- Comparing saliva collection and DNA extraction methods for saliva-based microbiome profiling.Frontiers in microbiology · 2026Article
- The role ofFrontiers in oral health · 2026Review
174 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite advancement in cancer treatment, oral cancer has a poor prognosis and is often detected at late stage. To overcome these challenges, investigators should search for early diagnostic and prognostic biomarkers. More than 700 bacterial species reside in the oral cavity. The oral microbiome population varies by saliva and different habitats of oral cavity. Tobacco, alcohol, and betel nut, which are causative factors of oral cancer, may alter the oral microbiome composition. Both pathogenic and commensal strains of bacteria have significantly contributed to oral cancer. Numerous bacterial species in the oral cavity are involved in chronic inflammation that lead to development of oral carcinogenesis. Bacterial products and its metabolic by-products may induce permanent genetic alterations in epithelial cells of the host that drive proliferation and/or survival of epithelial cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.