Evidence map›Paper›PMID 31370354›Full record

ArticleInternational journal of molecular sciences2019

Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with

Fabio Coppedè, Andrea Stoccoro, Pierpaola Tannorella, Roberta Gallo, Vanessa Nicolì, Lucia Migliore

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Genes · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Epigenetics of Male Infertility: The Role of DNA Methylation.Frontiers in cell and developmental biology · 2021
    Review
  18. Correlation Analysis BetweenFrontiers in oncology · 2021
    Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fabio CoppedèDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy. fabio.coppede@med.unipi.it.
Andrea StoccoroDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
Pierpaola TannorellaDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
Roberta GalloDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
Vanessa NicolìDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
Lucia MiglioreDepartment of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
University of Pisa · ITUniversity of Siena · IT

Funding

Ministero della Salute GR-2009-1606229
6 · The paper itself

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a pivotal enzyme in the one-carbon metabolism, a metabolic pathway required for DNA synthesis and methylation reactions.

Indexed as

DNA MethylationEpigenesis, GeneticPolymorphism, Single Nucleotide5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAgedAged, 80 and overDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BFemaleFerredoxin-NADP ReductaseFolic AcidGenotypeHealthy VolunteersHumansMale5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDNMT3A protein, humanFerredoxin-NADP ReductaseFolic AcidMethioninemethionine synthase reductaseMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanMTR protein, humanReduced Folate Carrier ProteinSLC19A1 protein, humanThymidylate SynthaseTYMS protein, humanDNMT3Bepigeneticsfolate metabolismmethylationmethylenetetrahydrofolate reductaseMTHFRone-carbon metabolismpolymorphisms

Identifiers

PMID31370354
PMCPMC6696388
OpenAlexW2964781294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.