ArticleJournal of clinical medicine2019
Reliability of Instantaneous Wave-Free Ratio (iFR) for the Evaluation of Left Main Coronary Artery Lesions.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- The Role of Circulating Biomarkers in Patients with Coronary Microvascular Disease.Biomolecules · 2025Review
- Management of Stent Underexpansion and Aorto-ostial Lesions.Interventional cardiology (London, England) · 2024Review
- Left Main Coronary Artery Percutaneous Coronary Intervention.Journal of clinical medicine · 2022Article
- Diagnostic performance of deep learning and computational fluid dynamics-based instantaneous wave-free ratio derived from computed tomography angiography.BMC cardiovascular disorders · 2022Observational
- Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease.Circulation. Cardiovascular interventions · 2021Observational
- Prediction of Significant Coronary Artery Disease Through Advanced Echocardiography: Role of Non-invasive Myocardial Work.Frontiers in cardiovascular medicine · 2021Article
- Physiology-Based Revascularization of Left Main Coronary Artery Disease.Journal of interventional cardiology · 2021Review
- Review
- Non-hyperaemic coronary pressure measurements to guide coronary interventions.Nature reviews. Cardiology · 2020Review
- Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics.Journal of clinical medicine · 2020Review
- Current Use and Trends in Unprotected Left Main Coronary Artery Percutaneous Intervention.Current cardiology reports · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The assessment of the left main coronary artery (LMCA) by coronary angiography has several limitations. The fractional flow reserve (FFR) is useful for the functional evaluation of LMCA stenoses. The instantaneous wave-free ratio (iFR), a resting index, was developed to simplify functional coronary assessment. However, its performance for LMCA stenoses has yet to be explored. The iFR was measured at rest, and the FFR was measured under maximal hyperemia. We calculated that a sample size of 90 lesions would have provided 90% power at a 5% significance level to detect an Area Under the Curve (AUC) < 0.7 for the iFR to identify FFR-positive stenoses. A total of 91 measurements were performed on angiographically intermediate LMCA stenoses at three centers. The comparison between the iFR and the FFR showed a significant correlation (r = 0.67,
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Registered trials
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