Evidence map›Paper›PMID 31370348›Full record

ArticleViruses2019

Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study.

Yomani D Sarathkumara, Chandika D Gamage, Sithumini Lokupathirage, Devinda S Muthusinghe, Nishantha Nanayakkara, Lishanthe Gunarathne, Kenta Shimizu, Yoshimi Tsuda, Jiro Arikawa, Kumiko Yoshimatsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yomani D SarathkumaraDepartment of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka.
Chandika D GamageDepartment of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka.
Sithumini LokupathirageDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Devinda S MuthusingheGraduate School of Infectious Diseases, Hokkaido University, Sapporo 060-8638, Japan.
Nishantha NanayakkaraNephrology and Transplantation Unit, Teaching Hospital Kandy, Kandy 20000, Sri Lanka.
Lishanthe GunarathneRenal Clinic, District Hospital, Girandurukotte 90750, Sri Lanka.
Kenta ShimizuDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Yoshimi TsudaDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Jiro ArikawaDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan.
Kumiko YoshimatsuDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan. yosimatu@med.hokudai.ac.jp.
Hokkaido University · JPUniversity of Peradeniya · LKTeaching Hospital Kandy · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants' demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.

Indexed as

AdultCapsid ProteinsCase-Control StudiesCross-Sectional StudiesEndemic DiseasesFarmersFemaleFluorescent Antibody Technique, IndirectGeographyHantavirus InfectionsHumansMaleOrthohantavirusRenal Insufficiency, ChronicRisk FactorsSerologic TestsCapsid Proteinsnucleocapsid protein, Hantaan virusViral Core ProteinsrodentThailand orthohantavirustropical nephropathy

Identifiers

PMID31370348
PMCPMC6723923
OpenAlexW2966813138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.