Evidence map›Paper›PMID 31370326›Full record

ArticleInternational journal of molecular sciences2019

Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis.

Theresa Hildegard Wirtz, Petra Fischer, Christina Backhaus, Irina Bergmann, Elisa Fabiana Brandt, Daniel Heinrichs, Maria Teresa Koenen, Kai Markus Schneider, Thomas Eggermann, Ingo Kurth and 7 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Theresa Hildegard WirtzDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany. thwirtz@ukaachen.de.
Petra FischerDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Christina BackhausInstitute of Human Genetics, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Irina BergmannDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Elisa Fabiana BrandtDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Daniel HeinrichsDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Maria Teresa KoenenDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Kai Markus SchneiderDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Thomas EggermannInstitute of Human Genetics, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Ingo KurthInstitute of Human Genetics, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Christian StoppeDepartment of Intensive Care Medicine, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Jürgen BernhagenChair of Vacular Biology, Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-University (LMU), 81377 Munich, Germany.
Tony BrunsDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Janett FischerMunich Cluster for Systems Neurology (EXC 2145 SyNergy), 81377 Munich, Germany.
Thomas BergSection of Hepatology, Clinic for Gastroenterology, University Hospital Leipzig, 04103 Leipzig, Germany.
Christian TrautweinDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
Marie-Luise BerresDepartment of Internal Medicine III, RWTH Aachen University Hospital, 52074 Aachen, Germany.
RWTH Aachen University · DEMunich Cluster for Systems Neurology · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two polymorphisms in the promoter region of macrophage migration inhibitory factor (MIF) - rs755622 and rs5844572 - exhibit prognostic relevance in inflammatory diseases. The aim of this study was to investigate a correlation between these MIF promoter polymorphisms and the severity of hepatitis C virus (HCV)-induced liver fibrosis. Our analysis included two independent patient cohorts with HCV-induced liver fibrosis (504 and 443 patients, respectively). The genotype of the single nucleotide polymorphism (SNP) -173 G/C and the repeat number of the microsatellite polymorphism -794 CATT

Indexed as

Genetic Predisposition to DiseaseAdultAgedAged, 80 and overAllelesCarcinoma, HepatocellularCohort StudiesElasticity Imaging TechniquesFemaleGene ExpressionGene FrequencyHepacivirusHepatitis C, ChronicHeterozygoteHomozygoteHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanbiomarkerHCVhepatocellular carcinomaliver fibrosismacrophage migration inhibitory factorpromoter polymorphisms

Identifiers

PMID31370326
PMCPMC6696142
OpenAlexW2965516481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.