Evidence map›Paper›PMID 31370263›Full record

ReviewInternational journal of molecular sciences2019

Chemerin and Cancer.

Oliver Treeck, Christa Buechler, Olaf Ortmann

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Article
  6. Chemerin/ChemerinR1 axis and inflammation-related diseases.Frontiers in molecular biosciences · 2026
    Review
  7. Article
  8. Review
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  12. Article
  13. Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Oliver TreeckDepartment of Obstetrics and Gynecology, University Medical Center Regensburg, 93053 Regensburg, Germany. otreeck@caritasstjosef.de.
Christa BuechlerDepartment of Internal Medicine I, University Medical Center Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-5635-3994
Olaf OrtmannDepartment of Obstetrics and Gynecology, University Medical Center Regensburg, 93053 Regensburg, Germany.
University Hospital Regensburg · DE

Funding

Deutsche Forschungsgemeinschaft BU 1141/13-1.
6 · The paper itself

Abstract

Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an important function of chemerin in cancer. Chemerin's main cellular receptors, chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) are expressed in most normal and tumor tissues. Chemerin's role in cancer is considered controversial, since it is able to exert both anti-tumoral and tumor-promoting effects, which are mediated by different mechanisms like recruiting innate immune defenses or activation of endothelial angiogenesis. For this review article, original research articles on the role of chemerin and its receptors in cancer were considered, which are listed in the PubMed database. Additionally, we included meta-analyses of publicly accessible DNA microarray data to elucidate the association of expression of chemerin and its receptors in tumor tissues with patients' survival.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsChemokinesDatabases, GeneticDisease Models, AnimalEndothelium, VascularHumansImmunity, InnateInflammationNeoplasmsNeovascularization, PathologicReceptors, CCRReceptors, ChemokineReceptors, G-Protein-CoupledSignal TransductionSurvival AnalysisCCRL2 protein, humanChemokinesCMKLR1 protein, humanGPR1 protein, humanRARRES2 protein, humanReceptors, CCRReceptors, ChemokineReceptors, G-Protein-Coupledadipokinecancerchemerinleukocyte

Identifiers

PMID31370263
PMCPMC6695761
OpenAlexW2966755732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.