Evidence map›Paper›PMID 31370252›Full record

ReviewJournal of functional biomaterials2019

Stimuli-Responsive Drug Release from Smart Polymers.

Carlos M Wells, Michael Harris, Landon Choi, Vishnu Priya Murali, Fernanda Delbuque Guerra, J Amber Jennings

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Review
  2. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos M WellsDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA. cwells3@memphis.edu.ORCID 0000-0003-4835-7503
Michael HarrisDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
Landon ChoiDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
Vishnu Priya MuraliDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
Fernanda Delbuque GuerraDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
J Amber JenningsDepartment of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.ORCID 0000-0002-2760-6948

Funding

Foundation for the National Institutes of Health R01AR066050Foundation for the National Institutes of Health R01DE026759Tennessee Doctoral Scholars Fellowship 0000002017
6 · The paper itself

Abstract

Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release in response to either chemical, physical, or biological triggers. The stimuli-responsiveness of smart biomaterials may improve spatiotemporal specificity of release. The material design may be used to tailor smart polymers to release a drug when particular stimuli are present. Smart biomaterials may use internal or external stimuli as triggering mechanisms. Internal stimuli-responsive smart biomaterials include those that respond to specific enzymes or changes in microenvironment pH; external stimuli can consist of electromagnetic, light, or acoustic energy; with some smart biomaterials responding to multiple stimuli. This review looks at current and evolving stimuli-responsive polymeric biomaterials in their proposed applications.

Indexed as

drug deliverydrug releaseenzyme-responsive materialspH-responsive materialsshape-memory materialsstimuli-responsivenessthermo-responsive materials

Identifiers

PMID31370252
PMCPMC6787590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.