Evidence map›Paper›PMID 31370247›Full record

ArticleCells2019

Destabilization of Eukaryote mRNAs by 5' Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway.

Barbara Gorgoni, Yun-Bo Zhao, J Krishnan, Ian Stansfield

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Barbara GorgoniInstitute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Yun-Bo ZhaoDepartment of Chemical Engineering, Centre for Process Systems Engineering, Institute for Systems and Synthetic Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0002-3684-5297
J KrishnanDepartment of Chemical Engineering, Centre for Process Systems Engineering, Institute for Systems and Synthetic Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. j.krishnan@imperial.ac.uk.
Ian StansfieldInstitute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. i.stansfield@abdn.ac.uk.ORCID 0000-0002-7242-7906
Imperial College London · GBUniversity of Aberdeen · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I020926/1Biotechnology and Biological Sciences Research Council BB/N017161/1
6 · The paper itself

Abstract

In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3'-5' mRNA interactions as part of an mRNA closed loop. It is however unclear how ribosome recycling on a closed loop mRNA is influenced by the proximity of the stop codon to the poly(A) tail, and how post-termination ribosome recycling affects mRNA stability. We show that in a yeast disabled for nonsense mediated mRNA decay (NMD), a

Indexed as

ATP-Binding Cassette TransportersCodon, TerminatorModels, TheoreticalNonsense Mediated mRNA DecayPhosphoglycerate KinaseProtein BiosynthesisRibosomesRNA, MessengerRNA StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsATP-Binding Cassette TransportersCodon, TerminatorPhosphoglycerate KinaseRLI1 protein, S cerevisiaeRNA, MessengerSaccharomyces cerevisiae Proteinsmathematical modellingmRNA decaySaccharomyces cerevisiaetranslationtranslational regulation

Identifiers

PMID31370247
PMCPMC6721604
OpenAlexW2966715402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.