Evidence map›Paper›PMID 31370031›Full record

ArticleAging2019

Genome-wide association study identifies

Kai-Xin Dou, Can Zhang, Chen-Chen Tan, Wei Xu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kai-Xin DouDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Can ZhangGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases (MIND), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Jie-Qiong LiDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Xi-Peng CaoClinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China.
Jin-Tai YuDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Qingdao University · CNFudan University · CNHarvard University · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Brain amyloid deposition is an early pathological event in Alzheimer's disease (AD), and abnormally low levels amyloid-β

Indexed as

Genome-Wide Association StudyAgedAged, 80 and overAmyloid beta-PeptidesAtrophyBiomarkersCognitive DysfunctionDementiaFemaleHeterozygoteHippocampusHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersCBFA2T3 protein, humanPeptide FragmentsRepressor ProteinsAlzheimer’s diseaseamyloidcerebrospinal fluidgeneticsGWAS

Identifiers

PMID31370031
PMCPMC6710044
OpenAlexW2965706688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.