ArticleCancer epidemiology2019
High parental occupational social contact and risk of childhood hematopoietic, brain and bone cancers.
Article in Cancer epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Paternal exposure to hydrocarbon solvents in the workplace and cancer risk in children and adolescents.Journal of exposure science & environmental epidemiology · 2026Article
- Childhood cancer risk in offspring of mothers occupationally exposed to hydrocarbon solvents.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026Article
- Household size, T regulatory cell development, and early allergic disease: a birth cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Cohort study of familial viral hepatitis and risks of paediatric cancers.International journal of epidemiology · 2022Article
- Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.Cancer causes & control : CCC · 2021Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe etiology of childhood cancer is largely unknown, though some research suggests an infectious origin of hematopoietic, central nervous system (CNS) and bone cancers.
methodsWe examined parental occupational social contact as a proxy for exposure to infectious agents and risk of childhood cancer. This population-based case-control study utilized a linkage of four Danish data-registries, and included 3581 cases (<17 years, diagnosed 1973-2012) and 358,100 age-matched controls. We examined the risks of leukemia, lymphoma, CNS and bone cancer related to high occupational social contact from (1) conception to birth and (2) birth to diagnosis.
resultsAcute lymphoblastic leukemia (ALL) and bone cancer were inversely associated with high maternal social contact from conception to birth (OR: 0.86, 95% CI: 0.67-1.10) and birth to diagnosis (OR: 0.54, 95% CI: 0.34-0.86). Children of fathers with high social contact from birth to diagnosis had an increased risk of bone cancers, particularly in rural areas (OR: 1.65, 95% CI: 1.03-2.63). Parental social contact was associated with increased risk of astrocytoma, with strongest associations found in first-born children (maternal: OR: 1.54, 95% CI: 1.02-2.32; paternal: OR: 1.82, 95% CI: 1.05-3.17).
conclusionOur results support the notion of a role of infections for some cancer types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.