Evidence map›Paper›PMID 31369720›Full record

ArticleThe American journal of medicine2020

Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study.

George R Washko, Laura A Colangelo, Raul San José Estépar, Samuel Y Ash, Surya P Bhatt, Yuka Okajima, Kiang Liu, David R Jacobs, Carlos Iribarren, Bharat Thyagarajan and 6 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Associations between life-course FEVThe Lancet. Respiratory medicine · 2025
    Article
  5. Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
  7. BEACON: A Missing Piece of the Puzzle for Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

George R WashkoDivision of Pulmonary and Critical Care Medicine, Boston, Mass; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, Mass. Electronic address: Gwashko@BWH.Harvard.edu.
Laura A ColangeloDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Raul San José EstéparApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, Mass; Department of Radiology, Brigham and Women's Hospital, Boston, Mass.
Samuel Y AshDivision of Pulmonary and Critical Care Medicine, Boston, Mass; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, Mass.
Surya P BhattLung Health Center, Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham.
Yuka OkajimaDivision of Pulmonary and Critical Care Medicine, Boston, Mass; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, Mass.
Kiang LiuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis.
Carlos IribarrenDivision of Research, Kaiser Permanente of Northern California, Oakland.
Bharat ThyagarajanDepartment of Pathology and Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis.
Cora E LewisDepartment of Epidemiology, University of Alabama-, Birmingham.
Rajesh KumarDivision of Allergy and Clinical Immunology, Department of Pediatrics, Northwestern University and The Ann & Robert H. Lurie Children's Hospital of Chicago, Ill.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor.
Mark T DransfieldLung Health Center, Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham.
Mercedes R CarnethonDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Ravi KalhanDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Northwestern University · USBrigham and Women's Hospital · USUniversity of Alabama at Birmingham · USKaiser Permanente · USLurie Children's Hospital · USMinnesota Department of Health · USPulmonary and Critical Care Associates · USUniversity of Michigan–Ann Arbor · USUniversity of Minnesota · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
Computed Tomographic characterization of subjects enrolled in the STATCOPE trialR01HL107246 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WASHKO, GEORGE R · 2011 to 2014
$1.7M
Characterization of Early Response to Chronic Lung Injury using Chest CTK08HL145118 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ASH, SAMUEL · 2019 to 2022
$681k
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS K08 HL145118NHLBI NIH HHS L30 HL134158NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL107246NHLBI NIH HHS R01 HL116931NHLBI NIH HHS R01 HL122477NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

backgroundPeak lung function and rate of decline predict future airflow obstruction and nonrespiratory comorbid conditions. Associations between lung function trajectories and emphysema have not been explored.

methodsUsing data from the population-based CARDIA Study, we sought to describe the prevalence of visually ascertained emphysema at multiple time points and contextualize its development based upon participant's adult life course measures of lung function. There were 3171 men and women enrolled at a mean age of 25 years, who underwent serial spirometric examinations through a mean age of 55 years. Trajectories for the change in percent-predicted forced expiratory volume in one second (FEV

resultsWe identified 5 trajectories describing peak and change in FEV

conclusionsLower peak and accelerated decline in FEV

Indexed as

Pulmonary EmphysemaRespiratory Function TestsAdultCohort StudiesFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedOdds RatioRisk FactorsSpirometryEmphysema riskLung function trajectory

Identifiers

PMID31369720
PMCPMC6980254
OpenAlexW2965035271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.