ArticleInvestigative ophthalmology & visual science2019
Variation of Peripapillary Scleral Shape With Age.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation.Experimental eye research · 2025Article
- Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative ophthalmology & visual science · 2025Article
- Effect of Deep Optic Nerve Head Morphology on Lamina Cribrosa and Peripapillary Scleral Configurations in Healthy Eyes.Investigative ophthalmology & visual science · 2025Article
- Ciliary muscle traction during accommodation is able to induce optic nerve head deformation.Eye (London, England) · 2025Article
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Lamina Cribrosa Configurations in Highly Myopic and Non-Highly Myopic Eyes: The Beijing Eye Study.Investigative ophthalmology & visual science · 2024Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Pediatric Optic Disc and Peripapillary Strain During Horizontal Eye Rotation.Current eye research · 2024Article
- Optical Coherence Tomographic Optic Nerve Head Morphology in Myopia III: The Exposed Neural Canal Region in Healthy Eyes-Implications for High Myopia.American journal of ophthalmology · 2024Article
- Parapapillary gamma zone associated with increased peripapillary scleral bowing: the Beijing Eye Study 2011.The British journal of ophthalmology · 2023Article
- Deep Optic Nerve Head Morphology in Tilted Disc Syndrome and Its Clinical Implication on Visual Damage.Investigative ophthalmology & visual science · 2023Article
- OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.American journal of ophthalmology · 2023Article
- Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.American journal of ophthalmology · 2023Observational
- Aging Effects on Optic Nerve Neurodegeneration.International journal of molecular sciences · 2023Review
- Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture.Eye and vision (London, England) · 2023Article
- Characteristics of the optic disc in young people with high myopia.BMC ophthalmology · 2022Article
- A Review of the Methods of Non-Invasive Assessment of Intracranial Pressure through Ocular Measurement.Bioengineering (Basel, Switzerland) · 2022Review
- A New Smartphone-Based Optic Nerve Head Biometric for Verification and Change Detection.Translational vision science & technology · 2021Article
- Optical Coherence Tomography Imaging of the Lamina Cribrosa: Structural Biomarkers in Nonglaucomatous Diseases.Journal of ophthalmology · 2021Review
- Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset.American journal of ophthalmology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Purpose: To define the shape of the anterior surface of the peripapillary sclera (PPS) and evaluate its relationship with age and ocular determinants in a population-based Chinese cohort. Methods: The optic nerve heads of 619 healthy Chinese subjects were imaged with spectral-domain optical coherence tomography. To assess the shape of the PPS/Bruch's membrane (BM), we measured the angle between a line parallel to the nasal anterior PPS/BM boundary and one parallel to the temporal side. A negative value indicated that the PPS/BM followed an inverted v-shaped configuration (peak pointing toward the vitreous), whereas a positive value indicated that it followed a v-shaped configuration (peak pointing toward the orbital tissues). A linear regression model was used to evaluate the relationship between the PPS angle and other ocular parameters. Results: The mean PPS angle was 3.68° ± 6.73° and the BM angle was 9.69° ± 5.05°. The PPS angle increased on average by 0.233 deg/y. A v-shaped PPS was significantly associated with age (β = 0.087, P = 0.004), peripapillary choroidal thickness (β = -0.479, P < 0.001), lamina cribrosa depth (β = 0.307, P < 0.001), and BM angle (β = 0.487, P < 0.001) after adjusting for best corrected visual acuity, central corneal thickness, and axial length. Conclusions: The anterior surface of PPS of an elderly adult population had a v-shaped configuration and was more pronounced with increasing age, thin peripapillary choroid, and a deep cup. Such a change in shape with age could have an impact on the biomechanical environment of the optic nerve head.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.