Evidence map›Paper›PMID 31369634›Full record

ArticlePloS one2019

IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate.

Adam M Corrigan, Johan Karlsson, Jan Wildenhain, Laurent Knerr, Maria Ölwegård-Halvarsson, Maria Karlsson, Svenja Lünse, Yinhai Wang

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adam M CorriganDiscovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.ORCID 0000-0001-5142-6579
Johan KarlssonDiscovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Jan WildenhainDiscovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Laurent KnerrResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Maria Ölwegård-HalvarssonResearch and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Maria KarlssonResearch and Early Development, Respiratory, Inflammation and Autoimmune, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Svenja LünseDiscovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Yinhai WangDiscovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents a MATLAB-based software package for high-throughput microscopy image analysis development, making such development more accessible for a large user community. The toolbox provides a GUI and a number of analysis workflows, and can serve as a general framework designed to allow for easy extension. For a new application, only a minor part of the object-oriented code needs to be replaced by new components, making development efficient. This makes it possible to quickly develop solutions for analysis not available in existing tools. We show its use in making a tool for quantifying intracellular transport of internalized peptide-drug conjugates. The code is freely available as open source on GitHub (https://github.com/amcorrigan/ia-lab).

Indexed as

Image Processing, Computer-AssistedMolecular Targeted TherapyAlgorithmsBiological TransportGlucagon-Like Peptide-1 ReceptorHumansPeptidesSoftwareTransferrinGlucagon-Like Peptide-1 ReceptorPeptidesTransferrin

Identifiers

PMID31369634
PMCPMC6675096

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.