ArticlePloS one2019
Impact of age on stage-specific mortality in patients with gastric cancer: A long-term prospective cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Prognostic Value of the Gustave Roussy Immune Score in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant FLOT Chemotherapy: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Longitudinal trajectories of nutritional markers in patients with de novo Stage IV gastric cancer: a descriptive analysis using one-year survival as a reference.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Population ageing and gastric cancer mortality burden in China, 2008-2021: a nationwide analysis with projections to 2036.Frontiers in public health · 2026Article
- Trends in Stomach Cancer Burden in China: A Joinpoint and APC Analysis Based on GBD 2021.Journal of gastroenterology and hepatology · 2025Article
- Survival Outcomes Between Minimally Invasive and Open Gastrectomy in Early and Locally Advanced Gastric Adenocarcinoma in a Western Center.Journal of gastrointestinal cancer · 2025Article
- Preoperative sarcopenia and postoperative accelerated muscle loss negatively impact survival after resection of locally advanced gastric cancer.BMC cancer · 2025Article
- Effect of Age at Diagnosis on the Prognosis of Gastric Cancer Patients: A Population-Based Study in Georgia.Cureus · 2024Article
- Development of a gastric cancer risk calculator for questionnaire-based surveillance of Iranian dyspeptic patients.BMC gastroenterology · 2024Article
- Efficacy and safety of chemotherapy in young patients with advanced gastroesophageal adenocarcinoma: data from the Spanish AGAMENON-SEOM registry.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Clinicopathological characteristics, survival outcome and prognostic factors of very young gastric cancer.Clinical and experimental medicine · 2023Article
- Clinical Features and Survival of Young Adults with Stage IV Gastric Cancer: a Japanese Population-Based Study.Journal of gastrointestinal cancer · 2023Article
- Predictors of survival outcomes among patients with gastric cancer in a leading tertiary, teaching and referral hospital in Kenya.Cancer medicine · 2023Article
- Characteristics and Predictors of Long-Time Survivors in Non-Metastatic Gastric Signet Ring Cell Carcinoma: A Large Population-Based Study.International journal of general medicine · 2022Article
- M2 Macrophage-Based Prognostic Nomogram for Gastric Cancer After Surgical Resection.Frontiers in oncology · 2021Article
- Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis.Journal of cancer research and clinical oncology · 2020Article
- Treatment of Gastric Cancer Patients During COVID-19 Pandemic: The West is More Vulnerable.Cancer management and research · 2020Review
- Progressive and Prognostic Performance of an Extracellular Matrix-Receptor Interaction Signature in Gastric Cancer.Disease markers · 2020Article
- Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab.Case reports in gastroenterologyArticle
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Authors and funding
9 authors.
Funding
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Abstract
Controversies exist regarding the impact of age on gastric cancer-related mortality according to cancer stage. In our prospective cohort study, we evaluated the impact of age on stage-specific mortality in patients with gastric cancer. Between 2002 and 2006, patients with newly diagnosed gastric cancer were recruited from two university-affiliated hospitals in Korea. Follow-up data were updated regularly based on medical records and telephone surveys. Patients were classified into four subgroups according to age: <50, 50-59, 60-69, and 70-79 years. A total of 448 patients were followed up for 81.6 months (interquartile range, 25.0-139.3 months). The number of patients with stage I, II, III, and IV disease was 247, 74, 88, and 39, respectively. Overall, age was an independent risk factor for gastric cancer-specific mortality (hazard ratio [HR], [95% confidence interval (CI)]: 1.53 [0.91-2.57], 1.88 [1.21-2.91], and 2.64 [1.69-4.14] in the 50-59, 60-69, and 70-79 years groups, respectively, with the <50 years group as reference). In patients with stage I and II gastric cancer, the 70-79 years group was associated with a significantly higher rate of cancer-specific mortality than the <50 years group (stage I: HR [95% CI], 9.55 [2.11-43.12]; stage II: HR [95% CI], 7.17 [2.32-22.18]). However, age was not an independently associated factor for cancer-specific mortality in patients with stage III and IV gastric cancer. Although age was an independent risk factor for gastric cancer-related mortality in patients with gastric cancer, its impact may differ depending on the stage of cancer.
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