Evidence map›Paper›PMID 3136958›Full record

ArticleClinical and experimental immunology1988

Interleukin 2 receptor in patients with localized and systemic parasitic diseases.

O Josimovic-Alasevic, H Feldmeier, K Zwingenberger, G Harms, H Hahn, M Shrisuphanunt, T Diamantstein

Open access · greenAbstract read
In one paragraph

Article in Clinical and experimental immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  8. Soluble plasma IL-2 receptors and malaria.Clinical and experimental immunology · 1993
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  18. Soluble interleukin 2 receptor in atopic eczema.BMJ (Clinical research ed.) · 1989
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

O Josimovic-AlasevicInstitute of Immunology, Klinikum Steglitz Freie Universitat, Berlin, FRG.
H Feldmeier
K Zwingenberger
G Harms
H Hahn
M Shrisuphanunt
T Diamantstein
Freie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An enzyme-linked immunosorbent assay was used to quantify soluble interleukin 2 receptor (IL-2R) in the serum of patients with helminthic and protozoal infections. The results demonstrated that levels of IL-2R were normal in patients with helminthic infections limited to the intestinal tract (ascariasis, trichuriasis), but significantly elevated in patients with systemic or long-lasting infections (strongyloidiasis, schistosomiasis, fascioliasis, opisthorchiasis). In patients infected with Schistosoma mansoni levels of IL-2R were higher in those with the hepatosplenic than in those with the intestinal form of the disease. Patients with malaria also showed increased serum levels of IL-2R, irrespective whether the infection was caused by Plasmodium falciparum or P. vivax. No difference was observed between patients with acute or history of malaria. The highest levels of IL-2R were observed in patients with visceral leishmaniasis. Interestingly, in these patients the concentration of IL-2R correlated to specific antibody titre. The results are discussed in the context of preferential activation of T lymphocytes, B lymphocytes and/or macrophages during the course of the different parasitic infections investigated.

Indexed as

Enzyme-Linked Immunosorbent AssayHelminthiasisHumansInterleukin-2Leishmaniasis, VisceralLiver Diseases, ParasiticMalariaReceptors, Antigen, T-CellReceptors, ImmunologicReceptors, Interleukin-2Schistosomiasis mansoniInterleukin-2Receptors, Antigen, T-CellReceptors, ImmunologicReceptors, Interleukin-2

Identifiers

PMID3136958
PMCPMC1541536
OpenAlexW2412715193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.