ArticlePLoS biology2019
The lipidome of primary murine white, brite, and brown adipocytes-Impact of beta-adrenergic stimulation.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Quantitative MALDI-MSI Workflow for Lipids with a LC-MS-Based Quality Control Pipeline.ACS measurement science au · 2026Article
- Phospholipid Profiling Established by Structure-Rich Fragments for Molecular Species Level Shotgun Analysis.Rapid communications in mass spectrometry : RCM · 2026Article
- Emerging complexities of phospholipid metabolism in adipose tissue.Molecules and cells · 2026Review
- Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue.PLoS biology · 2026Article
- Fatty acid composition of lipid fractions in white- and brown-like adipocytes derived from human mesenchymal stem cells.Adipocyte · 2025Article
- Depot-specific roles for sphingosine kinase 1 in conversion of white adipose to thermogenic adipose.bioRxiv : the preprint server for biology · 2025Article
- Ceramide-induced FGF13 impairs systemic metabolic health.Cell metabolism · 2025Article
- Characteristics of T2* and anisotropy parameters in inguinal and epididymal adipose tissues after cold exposure in mice.Scientific reports · 2024Article
- Gene Therapy Approach for Treatment of Obese Agouti Mice.International journal of molecular sciences · 2024Article
- Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.Life science alliance · 2024Article
- Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress.EMBO reports · 2023Article
- Fat and inflammation: adipocyte-myeloid cell crosstalk in atherosclerosis.Frontiers in immunology · 2023Review
- Measurement of Intracellular Temperature in Brown Adipocytes Using a Cationic Fluorescent Polymeric Thermometer.Methods in molecular biology (Clifton, N.J.) · 2023Article
- RNA-Seq and lipidomics reveal different adipogenic processes between bovine perirenal and intramuscular adipocytes.Adipocyte · 2022Article
- Mass Spectrometry-Based Lipidomics of Brown Adipose Tissue and Plasma of New-Born Lambs Subjected to Short-Term Cold Exposure.Animals : an open access journal from MDPI · 2022Article
- Dietary PUFA Preferably Modify Ethanolamine-Containing Glycerophospholipids of the Human Plasma Lipidome.Nutrients · 2022Article
- Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.Nature communications · 2022Article
- The distinct phenotype of primary adipocytes and adipocytes derived from stem cells of white adipose tissue as assessed by Raman and fluorescence imaging.Cellular and molecular life sciences : CMLS · 2022Article
- Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Ether Lipids in Obesity: From Cells to Population Studies.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid species patterns are conserved within cells to maintain physicochemical properties of membranes and cellular functions. We present the lipidome, including sterols, glycerolipids (GLs), glycerophospholipids (GPLs), and sphingolipids (SLs), of primary ex vivo differentiated (I) white, (II) brite, and (III) brown adipocytes derived from primary preadipocytes isolated from (I) epididymal white, (II) inguinal white, and (III) intrascapular brown adipose tissue. Quantitative lipidomics revealed significantly decreased fractions of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), with longer (C > 36) and more polyunsaturated species, as well as lower levels of cardiolipin (CL) in white than in brite and brown adipocytes. Together, the brite and brown lipidome was comparable and indicates differences in membrane lipid packing density compared with white adipocytes. Changes in ceramide species profile could be related to the degree of browning. Beta-adrenergic stimulation of brown adipocytes led to generation of saturated lyso-PC (LPC) increasing uncoupling protein (UCP) 1-mediated leak respiration. Application of stable isotope labeling showed that LPC formation was balanced by an increased de novo synthesis of PC.
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