Observational studyCritical care medicine2019
Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes.
Observational study in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07114510 (OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)
Who cites it
30 citing papers in PubMed.
- Chest compressions superimposed with sustained inflations during cardiopulmonary resuscitation in asphyxiated pediatric piglets.Pediatric research · 2024Trial
- Trial
- Chest compression synchronized ventilation versus chest compression asynchronized ventilation in asphyxiated pediatric piglets-a randomized animal trial.Pediatric research · 2026Article
- Effects of Different Ventilation Rates on Resuscitation in a Porcine Ventricular Fibrillation Cardiac Arrest Model.Shock (Augusta, Ga.) · 2026Article
- Chest compression metrics during infant basic life support using 15:2 and 10:2 compression-ventilation ratios: a randomized crossover simulation study.Resuscitation plus · 2026Article
- Contemporary issues in pediatric prehospital airway management.Expert review of respiratory medicine · 2026Review
- RESCUER mobile app to support pediatric resuscitation: Study protocol for a randomized controlled trial.Contemporary clinical trials communications · 2025Article
- Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest.JAMA network open · 2025Article
- Resuscitation after birth and beyond in the neonatal intensive care unit: NRP or PALS?Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Resuscitation arterial waveform quantification and outcomes in pediatric bidirectional Glenn and Fontan patients.Pediatric research · 2025Article
- Article
- Ventilation Rates and Capnography in Pediatric Out-of-Hospital Cardiac Arrest with Advanced Airways.Prehospital emergency care · 2025Article
- ILCOR pediatric life support recommendations translation to constituent council guidelines: An emphasis on similarities and differences.Resuscitation · 2024Article
- Association Between Chest Compression Pause Duration and Survival After Pediatric In-Hospital Cardiac Arrest.Circulation · 2024Article
- Multiple Causes of Death Associated with Pediatric Cardiopulmonary Arrest from 1996 to 2019 in Brazil.Arquivos brasileiros de cardiologia · 2024Article
- Comparison of paediatric basic life support guidelines endorsed by member councils of Resuscitation Council of Asia.Resuscitation plus · 2023Review
- Pediatric in-hospital cardiac arrest: Respiratory failure characteristics and association with outcomes.Resuscitation · 2023Article
- A Randomized, Controlled Animal Study: 21% or 100% Oxygen during Cardiopulmonary Resuscitation in Asphyxiated Infant Piglets.Children (Basel, Switzerland) · 2022Article
- Global mortality of children after perioperative cardiac arrest: A systematic review, meta-analysis, and meta-regression.Annals of medicine and surgery (2012) · 2022Review
- Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest.Scientific reports · 2021Article
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Authors and funding
20 authors.
Funding
Abstract
objectivesThe objective of this study was to associate ventilation rates during in-hospital cardiopulmonary resuscitation with 1) arterial blood pressure during cardiopulmonary resuscitation and 2) survival outcomes.
designProspective, multicenter observational study.
settingPediatric and pediatric cardiac ICUs of the Collaborative Pediatric Critical Care Research Network. PATIENTS: Intubated children (≥ 37 wk gestation and < 19 yr old) who received at least 1 minute of cardiopulmonary resuscitation.
interventionsNone. MEASUREMENTS AND MAIN
resultsArterial blood pressure and ventilation rate (breaths/min) were manually extracted from arterial line and capnogram waveforms. Guideline rate was defined as 10 ± 2 breaths/min; high ventilation rate as greater than or equal to 30 breaths/min in children less than 1 year old, and greater than or equal to 25 breaths/min in older children. The primary outcome was survival to hospital discharge. Regression models using Firth penalized likelihood assessed the association between ventilation rates and outcomes. Ventilation rates were available for 52 events (47 patients). More than half of patients (30/47; 64%) were less than 1 year old. Eighteen patients (38%) survived to discharge. Median event-level average ventilation rate was 29.8 breaths/min (interquartile range, 23.8-35.7). No event-level average ventilation rate was within guidelines; 30 events (58%) had high ventilation rates. The only significant association between ventilation rate and arterial blood pressure occurred in children 1 year old or older and was present for systolic blood pressure only (-17.8 mm Hg/10 breaths/min; 95% CI, -27.6 to -8.1; p < 0.01). High ventilation rates were associated with a higher odds of survival to discharge (odds ratio, 4.73; p = 0.029). This association was stable after individually controlling for location (adjusted odds ratio, 5.97; p = 0.022), initial rhythm (adjusted odds ratio, 3.87; p = 0.066), and time of day (adjusted odds ratio, 4.12; p = 0.049).
conclusionsIn this multicenter cohort, ventilation rates exceeding guidelines were common. Among the range of rates delivered, higher rates were associated with improved survival to hospital discharge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.