Observational studyThe Journal of clinical investigation2019
Evidence-based recommendations for energy intake in pregnant women with obesity.
Observational study in The Journal of clinical investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01954342 (MomEE), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MomEE: Determinants of Gestational Weight Gain in Obese Pregnant Women
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Energy expenditure during pregnancy: a systematic review.Nutrition reviews · 2021Pooled it
- A Behavioral Lifestyle Intervention to Limit Gestational Weight Gain in Pregnant Women with Overweight and Obesity.Obesity (Silver Spring, Md.) · 2021Trial
- Innovative Clinical Pathways for Pregnant Women with Obesity: The Padua Project (Northeastern Italy).Journal of clinical medicine · 2026Article
- Gestational weight management in underserved mothers in the US.American journal of preventive medicine · 2026Article
- Dietary Intake and Eating Behavior During Pregnancy by Pre-Pregnancy Nutritional Status.Life (Basel, Switzerland) · 2026Article
- Medical nutrition therapy in physiological pregnancy and in pregnancy complicated by obesity and/or diabetes: SID-AMD recommendations.Acta diabetologica · 2026Article
- Estimating energy requirements from Dietary Reference Intakes for pregnant people with obesity using wearables.Obesity (Silver Spring, Md.) · 2025Article
- Article
- Influence of maternal α-lipoic acid supplementation in Sprague Dawley rats on maternal and fetal metabolic health in pregnancies complicated by obesity.The Journal of nutritional biochemistry · 2024Article
- Risk related to gestational weight loss among individuals with obesity: a population-based cohort study.Obesity (Silver Spring, Md.) · 2024Article
- Maternal obesity management: a narrative literature review of health policies.BMC women's health · 2024Review
- Weight Loss, Stability, and Low Weight Gain during Pregnancy among Individuals with Obesity: Associations with Adverse Perinatal Outcomes: An Observational Study.American journal of perinatology · 2024Observational
- Safety of low weight gain or weight loss in pregnancies with class 1, 2, and 3 obesity: a population-based cohort study.Lancet (London, England) · 2024Article
- Healthful Eating Behaviors among Couples Contribute to Lower Gestational Weight Gain.Nutrients · 2024Article
- Nutritional Intake in Dichorionic Twin Pregnancies: A Descriptive Analysis of a Multisite United States Cohort.Maternal and child health journal · 2024Article
- Gestational weight loss and fetal growth in uncomplicated pregnancies among women with obesity: a population-based retrospective cohort study.International journal of obesity (2005) · 2023Article
- New frontiers in the measurement of energy metabolism.American journal of physiology. Endocrinology and metabolism · 2023Article
- No strong evidence of the protein leverage hypothesis in pregnant women with obesity and their infants.Obesity (Silver Spring, Md.) · 2023Article
- The partner-an underutilized facilitator to support healthy gestational weight gain.BMC pregnancy and childbirth · 2023Article
- Prenatal weight and regional body composition trajectories and neonatal body composition: The NICHD Foetal Growth Studies.Pediatric obesity · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundIn women with obesity, excess gestational weight gain (≥270 g/week) occurs in two out of three pregnancies and contributes to metabolic impairments in both mother and baby. To improve obstetrical care, objectively assessed information on energy balance is urgently needed. The objective of this study was to characterize determinants of gestational weight gain in women with obesity.
methodsThis was a prospective, observational study of pregnant women with obesity. The primary outcome was energy intake calculated by the energy intake-balance method. Energy expenditure was measured by doubly-labeled water and whole-room indirect calorimetry and body composition as 3-compartment model by air displacement plethysmography and isotope dilution in early (13-16 weeks) and late pregnancy (35-37 weeks).
resultsIn pregnant women with obesity (n=54), recommended weight gain (n=8, 15%) during the second and third trimesters was achieved when energy intake was 125±52 kcal/d less than energy expenditure. In contrast, women with excess weight gain (67%) consumed 186±29 kcal/d more than they expended (P<0.001). Energy balance affected maternal adiposity (recommended: -2.5±0.8 kg fat mass, excess: +2.2±0.5, inadequate: -4.5±0.5, P<0.001), but not fetal growth. Weight gain was not related to demographics, activity, metabolic biomarkers, or diet quality. We estimated that energy intake requirements for recommended weight gain during the second and third trimesters were not increased as compared to energy requirements early in pregnancy (34±53 kcal/d, P=0.83).
conclusionsWe here provide the first evidence-based recommendations for energy intake in pregnant women with obesity. Contrary to current recommendations, energy intake should not exceed energy expenditure.
fundingThis study was funded by the National Institutes of Health (R01DK099175; Redman, U54GM104940 and P30DK072476; Core support).
trial registrationclinicaltrials.gov: NCT01954342.
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