ArticleCancer medicine2019
Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Periodontal Disease and Risk of Osteoradionecrosis in Patients with Head and Neck Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Carbon-ions, protons or photons for head and neck cancer radiotherapy-an in silico planning study.Physical and engineering sciences in medicine · 2026Article
- Article
- Advances in radiotherapy for mouth neoplasms: emerging technologies and future perspectives.Discover oncology · 2025Review
- Carbon Ion Radiotherapy in the Head and Neck Cancers Treatment and its Potential Role in Personalized Treatment Approach- A Review of the Current Knowledge.Current oncology reports · 2025Review
- Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy.Clinical and translational radiation oncology · 2025Article
- Distinct patterns of osteoradionecrosis after photon-based radiotherapy and carbon ion radiotherapy for unresectable adenoid cystic carcinoma of the head and neck: case series from two institutions.Acta oncologica (Stockholm, Sweden) · 2025Article
- An unusual case of oral mucosal melanoma successfully treated by carbon-ion radiotherapy.Oxford medical case reports · 2024Article
- Carbon-ion radiotherapy for clear cell odontogenic carcinomas.World journal of surgical oncology · 2024Article
- Salivary gland cancers in elderly patients: challenges and therapeutic strategies.Frontiers in oncology · 2022Review
- Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck.Diagnostics (Basel, Switzerland) · 2020Article
- Carbon Ion Therapy: A Modern Review of an Emerging Technology.Frontiers in oncology · 2020Review
- Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.Cancer medicine · 2019Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the efficacy and safety of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study.
methodsRetrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0-1 M0 status and were treated with carbon-ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed.
resultsSalivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1-3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow-up period was 31.1 months (range, 3-118 months). Three-year local control, progression-free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed.
conclusionsOral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon-ion radiation therapy.
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