ArticleOptics letters2019
Simultaneous photoacoustic imaging of intravascular and tissue oxygenation.
Article in Optics letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Ultrasound-guided sound speed correction for photoacoustic computed tomography.Photoacoustics · 2026Article
- Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease.Molecular imaging and biology · 2026Article
- Light-RepViTSR: ultra-lightweight super-resolution for real-time photoacoustic endoscopy in tumor biopsy.Frontiers in bioengineering and biotechnology · 2026Article
- Anthropomorphic tissue-mimicking phantoms for oximetry validation in multispectral optical imaging.Journal of biomedical optics · 2025Article
- Masterful macrophages: understanding and targeting activation dysfunction in diabetic wounds.Burns & trauma · 2025Review
- Microcirculation: Current Perspective in Diagnostics, Imaging, and Clinical Applications.Journal of clinical medicine · 2024Review
- Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery.Biosensors & bioelectronics · 2024Article
- A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential.Advanced therapeutics · 2024Article
- Testicular torsion diagnosis and injury assessment using photoacoustic oxygenation imaging.Photoacoustics · 2023Article
- Biomimetic Approach to Promote Cellular Uptake and Enhance Photoacoustic Properties of Tumor-Seeking Dyes.Journal of the American Chemical Society · 2023Article
- Review
- Photoacoustic imaging for the study of oxygen saturation and total hemoglobin in bone healing and non-union formation.Photoacoustics · 2022Article
- Modified norcyanines enable ratiometric pH imaging beyond 1000 nm.Biosensors & bioelectronics · 2022Article
- Detection of weak optical absorption by optical-resolution photoacoustic microscopy.Photoacoustics · 2022Article
- Targeted contrast agents and activatable probes for photoacoustic imaging of cancer.Chemical Society reviews · 2022Review
- Nanotech Probes: A Revolution in Cancer Diagnosis.Frontiers in oncology · 2022Review
- Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring.Experimental neurology · 2022Review
- Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.Frontiers in neuroscience · 2022Review
- High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.Photoacoustics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypoxia, a low tissue oxygenation condition caused by insufficient oxygen supply, leads to potentially irreversible tissue damage, such as brain infarction during stroke. Intravascular oxygenation has long been used by photoacoustic imaging, among other imaging modalities, to study hypoxia. However, intravascular oxygenation describes only the oxygen supply via microcirculation, which does not directly reflect the amount of free oxygen available for metabolism in the interstitial fluid. Therefore, to fully understand hypoxia, it is highly desirable to monitor blood oxygenation as well as tissue oxygenation during the same biological process. In this work, by combining high-resolution photoacoustic microscopy (PAM) and a novel bioreducible N-oxide-based hypoxia-sensitive probe HyP-650, we have demonstrated simultaneous imaging of intravascular oxygenation and tissue hypoxia. We have established detailed chemical, optical, and photoacoustic properties of HyP-650 for hypoxic activation in vitro and in living cells. We have also performed PAM on hindlimb ischemia models and tumor-bearing mice to study the correlation between intravascular oxygenation and tissue oxygenation at various hypoxic levels. We expect that Hyp-650 enhanced photoacoustic imaging will find a variety of applications in brain and cancer research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.