ArticleHelicobacter2019
Online registry for nationwide database of Helicobacter pylori eradication in Korea: Correlation of antibiotic use density with eradication success.
Article in Helicobacter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Ten-day bismuth-containing quadruple therapy versus 7-day proton pump inhibitor-clarithromycin containing triple therapy as first-line empirical therapy for the Helicobacter pylori infection in Korea: a randomized open-label trial.BMC gastroenterology · 2021Trial
- A Nationwide Trend Analysis ofGut and liver · 2026Article
- Diagnosis and treatment ofFuture microbiology · 2025Review
- Korean Registry on the Current Management ofGut and liver · 2025Article
- Translating evidence into action: overcoming barriers to gastric cancer prevention in Aotearoa.Journal of the Royal Society of New Zealand · 2025Review
- Comparison of Amoxicillin Administered Twice versus Four Times a Day in First-LineMicroorganisms · 2024Article
- Developing Operational Definitions Related toJournal of Korean medical science · 2023Article
- [Vonoprazan-based Dual and Triple Therapy forThe Korean journal of helicobacter and upper gastrointestinal research · 2023Article
- Management ofGut and liver · 2022Review
- Current guidelines forWorld journal of clinical cases · 2022Review
- Efficacy of Twice a Day Bismuth Quadruple Therapy for Second-Line Treatment ofJournal of personalized medicine · 2022Article
- Efficacy of Seven-Day Potassium-Competitive Acid Blocker-Based First-LineYonsei medical journal · 2021Article
- Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin forAntibiotics (Basel, Switzerland) · 2021Article
- Current status ofWorld journal of gastroenterology · 2020Article
- Article
- Online registry for nationwide database of Helicobacter pylori eradication in Korea: Correlation of antibiotic use density with eradication success.Helicobacter · 2019Article
- Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
backgroundThe Helicobacter pylori eradication rate has decreased with increasing antibiotic resistance. We conducted a prospective, nationwide, multicenter registry study to monitor the real status of H. pylori eradication therapy and to investigate the association between eradication success and antibiotic use density in Korea. MATERIALS AND
methodsWe enrolled 9318 patients undergoing H. pylori eradication therapy from 37 hospitals through "on-line database registry" from October 2010 to July 2015. Demographic data, detection methods, treatment indications, regimens, durations, compliance, adverse events, and eradication results were collected. The use of all commercially available eradication antibiotics was analyzed through the Korean National Health Insurance data of the Health Insurance Review and Assessment Service. The defined daily dose of antibiotics was used to standardize drug use comparisons.
resultsFinally, 6738 patients were analyzed. The overall eradication rate of first-line therapy was 71.8%. The eradication success rates were 71.7%, 86.9%, and 74.0% for standard triple therapy for 7 days, quadruple therapy, and concomitant therapy, respectively. The eradication success rate in naive patients was higher than that in those who previously underwent H. pylori eradication. Eradication success was significantly associated with younger age, female sex, and high compliance. Regional differences in eradication rates were observed. The yearly use density of clarithromycin increased statistically in seven regions across the country from 2010 to 2015. The yearly use density of amoxicillin in the Gyeongsang and Chungcheong areas was significantly increased (P < .01), whereas that of other macrolides was significantly lower in the Gyeonggi area than in other areas (P = .01). The overall use of eradication antibiotics has increased while the eradication rate steadily decreased for 5 years. However, there was no significant correlation between antibiotic use density and eradication.
conclusionThere was no relationship between the eradication rate and antibiotic use density in Korea.
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