ArticleThe EMBO journal2019
Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast.
Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- Guard-cell expression of abscisic acid receptors for engineering water-use-efficient plants without trade-offs in growth.The New phytologist · 2025Article
- DOG1 controls dormancy independently of ABA core signaling kinases regulation by preventing AFP dephosphorylation through AHG1.Science advances · 2025Article
- SnRK2 kinases sense molecular crowding and form condensates to disrupt ABI1 inhibition.Science advances · 2025Article
- Article
- Reconstitution of phytochrome A-mediated light modulation of the ABA signaling pathways in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hero or sidekick? Organellar reactive oxygen species during abscisic acid-induced stomatal closure.Plant physiology · 2023Article
- The Systems and Synthetic Biology of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- Abscisic acid agonists suitable for optimizing plant water use.Frontiers in plant science · 2022Article
- Hormonal and environmental signaling pathways target membrane water transport.Plant physiology · 2021Review
- Cellular Phosphorylation Signaling and Gene Expression in Drought Stress Responses: ABA-Dependent and ABA-Independent Regulatory Systems.Plants (Basel, Switzerland) · 2021Review
- Reconstitution of Cytokinin Signaling in Rice Protoplasts.International journal of molecular sciences · 2021Article
- Signaling mechanisms in abscisic acid-mediated stomatal closure.The Plant journal : for cell and molecular biology · 2021Review
- Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants.Nature communications · 2020Review
- Induction of Jasmonoyl-Isoleucine (JA-Ile)-DependentPlants (Basel, Switzerland) · 2020Article
- A Synthetic Approach Allows Rapid Characterization of the Maize Nuclear Auxin Response Circuit.Plant physiology · 2020Article
- MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response.Nature communications · 2020Article
- Article
- Toward a better understanding of signaling networks in plants: yeast has the power!The EMBO journal · 2019Article
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13 authors.
Funding
Abstract
The phytohormone abscisic acid (ABA) regulates plant responses to abiotic stress, such as drought and high osmotic conditions. The multitude of functionally redundant components involved in ABA signaling poses a major challenge for elucidating individual contributions to the response selectivity and sensitivity of the pathway. Here, we reconstructed single ABA signaling pathways in yeast for combinatorial analysis of ABA receptors and coreceptors, downstream-acting SnRK2 protein kinases, and transcription factors. The analysis shows that some ABA receptors stimulate the pathway even in the absence of ABA and that SnRK2s are major determinants of ABA responsiveness by differing in the ligand-dependent control. Five SnRK2s, including SnRK2.4 known to be active under osmotic stress in plants, activated ABA-responsive transcription factors and were regulated by ABA receptor complexes in yeast. In the plant tissue, SnRK2.4 and ABA receptors competed for coreceptor interaction in an ABA-dependent manner consistent with a tight integration of SnRK2.4 into the ABA signaling pathway. The study establishes the suitability of the yeast system for the dissection of core signaling cascades and opens up future avenues of research on ligand-receptor regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.