ArticleBritish journal of pharmacology2019
Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Sperm Ion Transporters and Channels in Human Asthenozoospermia: Genetic Etiology, Lessons from Animal Models, and Clinical Perspectives.International journal of molecular sciences · 2022Pooled it
- From Bench to Babies - Drug Development for Male Subfertility.Reproduction & fertility · 2024Article
- Article
- The sperm-specific KFrontiers in cell and developmental biology · 2024Article
- Effects of in vitro repaglinide supplementation on improving sperm motility parameters, viability, and DNA integrity in normozoospermic and asthenozoospermic men.JBRA assisted reproduction · 2023Article
- Control of intracellular pH and bicarbonate by CONature communications · 2023Article
- The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review.Current issues in molecular biology · 2023Review
- Elevated and Sustained Intracellular Calcium Signalling Is Necessary for Efficacious Induction of the Human Sperm Acrosome Reaction.International journal of molecular sciences · 2022Article
- Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.Human reproduction (Oxford, England) · 2022Article
- Lysophosphatidic Acid Improves Human Sperm Motility by Enhancing Glycolysis and Activating L-Type Calcium Channels.Frontiers in endocrinology · 2022Article
- Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm.Human reproduction (Oxford, England) · 2021Article
- Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CBMolecules (Basel, Switzerland) · 2021Review
- The CaThe Journal of biological chemistry · 2020Article
- Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia.Gastroenterology · 2020Article
- Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.British journal of pharmacology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeAsthenozoospermia is a leading cause of male infertility, but development of pharmacological agents to improve sperm motility is hindered by the lack of effective screening platforms and knowledge of suitable molecular targets. We have demonstrated that a high-throughput screening (HTS) strategy and established in vitro tests can identify and characterise compounds that improve sperm motility. Here, we applied HTS to identify new compounds from a novel small molecule library that increase intracellular calcium ([Ca EXPERIMENTAL APPROACH: A validated HTS fluorometric [Ca KEY
resultsFluorometric assays identified trequinsin as an efficacious agonist of [Ca CONCLUSION AND IMPLICATIONS: Trequinsin exhibits a novel pharmacological profile in human sperm and may be a suitable lead compound for the development of new agents to improve patient sperm function and fertilisation potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.