Evidence map›Paper›PMID 31368404›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Profiles of cortical inflammation in multiple sclerosis by

Elena Herranz, Céline Louapre, Constantina Andrada Treaba, Sindhuja T Govindarajan, Russell Ouellette, Gabriel Mangeat, Marco L Loggia, Julien Cohen-Adad, Eric C Klawiter, Jacob A Sloane and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Advanced MRI quantification of neuroinflammatory disorders.Journal of neuroscience research · 2022
    Article
  13. Review
  14. Article
  15. Cytokine Signalling at the Microglial Penta-Partite Synapse.International journal of molecular sciences · 2021
    Review
  16. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
  17. The correlation between circulating inflammatory, oxidative stress, and neurotrophic factors level with the cognitive outcomes in multiple sclerosis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Elena HerranzDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Harvard Medical School, Boston, MA, USA.
Céline LouapreDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Harvard Medical School, Boston, MA, USA.
Constantina Andrada TreabaDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Harvard Medical School, Boston, MA, USA.
Sindhuja T GovindarajanDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Russell OuelletteDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Gabriel MangeatDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Marco L LoggiaDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Harvard Medical School, Boston, MA, USA.
Julien Cohen-AdadInstitute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.
Eric C KlawiterHarvard Medical School, Boston, MA, USA/ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Jacob A SloaneHarvard Medical School, Boston, MA, USA/ Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Caterina MaineroDepartment of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA/ Harvard Medical School, Boston, MA, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USPolytechnique Montréal · CABeth Israel Deaconess Medical Center · USHarvard University · US

Funding

Imaging neuroglial mechanisms of neuropathic pain-opioid interaction in HIVR01DA047088 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO, RATAI, EVA-MARIA · 2018 to 2022
$4.3M
In-vivo imaging of spinal and brain glial activation in low back pain patientsR01NS095937 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5M
The Role of Brain Glial Activation in knee OstoarthritisR01NS094306 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5M
Cortical mechanisms of disease progression in early multiple sclerosisR01NS078322 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2013 to 2017
$1.9M
Identifying Early Failure to Anti-angiogenic Therapy in Recurrent GBMR01CA190901 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATAI, EVA-MARIA · 2015 to 2018
$1.4M
The Role of Neuroimmune Activation in Chronic Pain and Negative AffectR21NS087472 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2014 to 2015
$479k
NIDA NIH HHS R01 DA047088NINDS NIH HHS R01 NS078322NINDS NIH HHS R01 NS094306NINDS NIH HHS R01 NS095937NINDS NIH HHS R21 NS087472
6 · The paper itself

Abstract

backgroundNeuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis.

objectiveUsing

methodsMean

results

conclusion

Indexed as

Multiple SclerosisMultiple Sclerosis, Chronic ProgressiveHumansInflammationMagnetic Resonance ImagingPositron-Emission Tomography11C-PBR287T MRIcortical lesionsdemyelinationinflammationmicrogliaMultiple sclerosispositron emission tomographyT2* relaxometry

Identifiers

PMID31368404
PMCPMC6994367
OpenAlexW2964398132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.