Evidence map›Paper›PMID 31368399›Full record

ArticleMolecular pain

Morphine and HIV-1 gp120 cooperatively promote pathogenesis in the spinal pain neural circuit.

Yuqiang Shi, Subo Yuan, Shao-Jun Tang

Open access · goldAbstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  12. Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yuqiang Shi1 Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
Subo Yuan1 Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
Shao-Jun Tang1 Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-6076-5481
The University of Texas Medical Branch at Galveston · US

Funding

Wnt signaling in glial activation during HIV-associated chronic pain pathogenesisR01NS079166 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2012 to 2021
$5.5M
Cooperative mechanisms of HIV and opiods in pain pathogenisisR01DA050530 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M, TANG, SHAO-JUN · 2019 to 2023
$3.2M
Antiretroviral Therapy and Neuroinflammation in the CNSR01NS095747 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M · 2016 to 2020
$2.6M
Interplay of HIV-1 gp120 and opioids in astrocyte activationR01DA036165 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2013 to 2017
$1.9M
NIDA NIH HHS R01 DA036165NIDA NIH HHS R01 DA050530NINDS NIH HHS R01 NS079166NINDS NIH HHS R01 NS095747
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAstrocytesFemaleHIV Envelope Protein gp120MaleMiceMice, Inbred C57BLMorphineNeuralgiaSignal TransductionSpinal CordWnt-5a ProteinHIV Envelope Protein gp120MorphineWnt-5a ProteinastrocyteHIV-1inflammasomemorphineneuroinflammationopioidPainWnt

Identifiers

PMID31368399
PMCPMC6676262
OpenAlexW2965596422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.