ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020
The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES: A Single-Arm Clinical Trial.Annals of neurology · 2026Trial
- Efficacy of Ofatumumab and Teriflunomide in Patients With Relapsing MS From Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses.Neurology · 2024Trial
- Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.Nature genetics · 2026Article
- Differential results of genetic risk scoring for multiple sclerosis in European and African American populations.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Vitamin D receptor gene polymorphisms in patients with relapsing multiple sclerosis.European journal of translational myology · 2025Article
- Advances in Multiple Sclerosis.Biomedicines · 2025Article
- Review
- GWAS highlights the neuronal contribution to multiple sclerosis susceptibility.medRxiv : the preprint server for health sciences · 2024Article
- Descriptive Analysis of Health Disparities Between Black and White People With Multiple Sclerosis in the Deep South.International journal of MS care · 2024Article
- Inclusion of optic neuritis in dissemination in space improves the performance of McDonald 2017 criteria in Hispanic people with suspected multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Article
- ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.BMJ open · 2023Article
- Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population.European journal of neurology · 2023Article
- Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry.Brain communications · 2023Article
- Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients.Frontiers in immunology · 2023Review
- Disability outcomes in early-stage African American and White people with multiple sclerosis.Multiple sclerosis and related disorders · 2023Article
- Towards a global view of multiple sclerosis genetics.Nature reviews. Neurology · 2022Review
- Review
- Differences in Cardiometabolic Comorbidities Between Black and White Persons Living With Multiple Sclerosis.Archives of physical medicine and rehabilitation · 2022Article
- Genetics and functional genomics of multiple sclerosis.Seminars in immunopathology · 2022Review
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundSubstantial progress has been made toward unraveling the genetic architecture of multiple sclerosis (MS) within populations of European ancestry, but few genetic studies have focused on Hispanic and African American populations within the United States.
objectiveWe sought to test the relevance of common European MS risk variants outside of the major histocompatibility complex (
methodsGenotype data were available on 2652 Hispanics (1298 with MS, 1354 controls) and 2435 African Americans (1298 with MS, 1137 controls). We conducted single variant, pathway, and cumulative genetic risk score analyses.
resultsWe found less replication than statistical power suggested, particularly among African Americans. This could be due to limited correlation between the tested and causal variants within the sample or alternatively could indicate allelic and locus heterogeneity. Differences were observed between pathways enriched among the replicating versus all 200 variants. Although these differences should be examined in larger samples, a potential role exists for gene-environment or gene-gene interactions which alter phenotype differentially across racial and ethnic groups. Cumulative genetic risk scores were associated with MS within each study sample but showed limited diagnostic capability.
conclusionThese findings provide a framework for fine-mapping efforts in multi-ethnic populations of MS.
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