Evidence map›Paper›PMID 31368294›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Neurobiological commonalities and distinctions among 3 major psychiatric disorders: a graph theoretical analysis of the structural connectome

Shuai Wang, Gaolang Gong, Suyu Zhong, Jia Duan, Zhiyang Yin, Miao Chang, Shengnan Wei, Xiaowei Jiang, Yifang Zhou, Yanqing Tang and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  6. Negative symptoms are associated with modularity and thalamic connectivity in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Shuai WangFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Gaolang GongFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Suyu ZhongFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Jia DuanFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Zhiyang YinFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Miao ChangFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Shengnan WeiFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Xiaowei JiangFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Yifang ZhouFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Yanqing TangFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Fei WangFrom the Department of Psychiatry, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Yin, Tang, F. Wang); the State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China (Gong, Zhong); the Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Chang, Wei, Jiang, F. Wang); the Brain Function Research Section, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (S. Wang, Duan, Chang, Wei, Jiang, Zhou, Tang, F. Wang); and the Department of Gerontology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (Zhou, Tang).
Beijing Normal University · CNChina Medical University · CNFirst Hospital of China Medical University · CNMcGovern Institute for Brain Research · USShenyang First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: White matter network alterations have increasingly been implicated in major depressive disorder, bipolar disorder and schizophrenia. The aim of this study was to identify shared and distinct white matter network alterations among the 3 disorders. Methods: We used analysis of covariance, with age and gender as covariates, to investigate white matter network alterations in 123 patients with schizophrenia, 123 with bipolar disorder, 124 with major depressive disorder and 209 healthy controls. Results: We found significant group differences in global network efficiency (F = 3.386, p = 0.018), nodal efficiency (F = 8.015, p < 0.001 corrected for false discovery rate [FDR]) and nodal degree (F = 5.971, pFDR < 0.001) in the left middle occipital gyrus, as well as nodal efficiency (F = 6.930, pFDR < 0.001) and nodal degree (F = 5.884, pFDR < 0.001) in the left postcentral gyrus. We found no significant alterations in patients with major depressive disorder. Post hoc analyses revealed that compared with healthy controls, patients in the schizophrenia and bipolar disorder groups showed decreased global network efficiency, nodal efficiency and nodal degree in the left middle occipital gyrus. Furthermore, patients in the schizophrenia group showed decreased nodal efficiency and nodal degree in the left postcentral gyrus compared with healthy controls. Limitations: Our findings could have been confounded in part by treatment differences. Conclusion: Our findings implicate graded white matter network alterations across the 3 disorders, enhancing our understanding of shared and distinct pathophysiological mechanisms across diagnoses and providing vital insights into neuroimaging-based methods for diagnosis and research.

Indexed as

AdolescentAdultBipolar DisorderConnectomeDiffusion Tensor ImagingEcho-Planar ImagingFemaleHumansImage Processing, Computer-AssistedMajor Depressive DisorderMaleMiddle AgedModels, TheoreticalNerve NetOccipital LobeSchizophrenia

Identifiers

PMID31368294
PMCPMC6919917
OpenAlexW2985650045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.